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AuthorZhao, Fei-Yi
AuthorFu, Qiang-Qian
AuthorZheng, Zhen
AuthorLao, Li-Xing
AuthorSong, Hua-Ling
AuthorShi, Zumin
Available date2020-04-06T06:53:46Z
Publication Date2020-04-01
Publication NameBioMed Research International
Identifierhttp://dx.doi.org/10.1155/2020/5901573
CitationZhao, F. Y., Fu, Q. Q., Zheng, Z., Lao, L. X., Song, H. L., & Shi, Z. (2020). Verum-versus Sham-Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta-Analysis. BioMed Research International, 2020.‏
ISSN2314-6133
URIhttp://hdl.handle.net/10576/13850
AbstractBackground. Alzheimer’s disease (AD) is a common health condition affecting senile people and leads to severe cognitive dysfunctions. Acupuncture has been shown to be a possible alternative natural remedy for AD in some animal studies. Objective. To perform a systematic review to identify the effect of verum-acupuncture compared with sham-acupuncture on learning and memory performance among animal models of AD. Methods. Experimental animal studies of treating AD via verum- and sham- acupuncture were searched in nine electronic databases, including Sciverse ScienceDirect, PubMed, Springer, Ebsco Medline, AMED, EMBASE (Elsevier), Scopus (Elsevier), PsycINFO (ProQuest), and OVID from the dates of the databases’ inception to June 2019. The Morris water maze test was considered as an outcome measure. The software Revman 5.3 and Stata 16.0 were used to conduct the meta-analysis. Heterogeneity was examined by using I2 statistics. The publication bias was assessed via Begg’s test by Stata 16.0. Results. Twelve studies involving 229 animals met the inclusion criteria. Most of the studies had a moderate quality according to SYRCLE's risk of bias tool for animal studies. The results of the meta-analysis indicated that verum-acupuncture could reduce the escape latency (MD = −12.90, 95% CI (−17.08, −8.71), ) and increase the time spent in the original platform quadrant (MD = 7.28, 95% CI (4.23, 10.33), ) and frequency of the crossing former platform (MD = 2.01, 95% CI (1.53, 2.50), ) compared with the sham-acupuncture. Conclusions. Acupuncture is effective in improving cognitive functions in AD animal models, and this benefit is more than just a placebo effect. Further clinical trials are needed to confirm the findings.
SponsorThis work was sponsored by the Teaching and Research Award Program for Outstanding Young Teachers, Shanghai Sanda University (No. 2018zz13) and Special Project for Clinical Research, Shanghai Municipal Health Commission (No. 20174Y0009). The publication of this article was funded by the Qatar National Library. The authors would like to extend their gratitude to Yuen-Shan Ho, from School of Nursing, The Hong Kong Polytechnic University, for inspiring them to seek the underlying research directions. Besides, the authors thank Hai-Dong Guo, from School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, for providing help in organizing the data and Yan Xu, the chair of Nursing Department, Shanghai Sanda University, for providing general support.
Languageen
Publisherhindawi
Subjectcognition
Alzheimer's disease
TitleVerum- versus Sham-Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta-Analysis
TypeArticle
Volume Number2020
ESSN2314-6141
dc.accessType Open Access


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