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AuthorBhatti S.A.
AuthorKhan M.Z.
AuthorSaleemi M.K.
AuthorHassan Z.U.
Available date2020-04-09T07:35:01Z
Publication Date2019
Publication NameFood and Chemical Toxicology
ResourceScopus
ISSN2786915
URIhttp://dx.doi.org/10.1016/j.fct.2019.110696
URIhttp://hdl.handle.net/10576/13940
AbstractOchratoxin A (OA), the secondary metabolite of certain Aspergillus and Penicillium species, is one of the potent biological immune-suppressor. The present study was designed to explore the in-vivo efficacy of Trichosporon mycotoxinivorans (TR); yeast strain isolated from the hindgut of the termite Mastotermes darwiniensis, against the immunotoxicity of OA in broiler birds. For this purpose, broiler chicks were offered diet added with TR (0.5, 1.0 or 2.0 g/kg feed) and/or OA (0.15, 0.3 or 1.0 mg/kg feed) for 42 days. Dietary OA at all levels, resulted in significant reduction (p ? 0.05) in the immune response of broiler birds as recorded by vacuolation and darkly stained pyknotic nuclei in bursa of Fabricius and thymus, humoral immune responses to sheep red blood cells (SRBC), in-vivo lymphoproliferative response to Phytohemagglutinin-P (PHA-P) and mononuclear phagocytic system function assay. Addition of TR in broiler diet significantly reduced (p ? 0.05) the immunotoxicity of OA at 0.15 and 0.30 mg/kg; however, against higher dietary level of OA (1.0 mg/kg), a partial protection was observed. Feeding TR alone had no immunomodulatory effect at any of tested level. Dietary addition of TR is proposed as an approach to combat the OA mediated immunological damages in broiler birds. - 2019
SponsorThe authors highly acknowledge the Higher Education Commission of Pakistan for funding this study to first author under HEC Indigenous PhD fellowship program batch VII. Appendix A
Languageen
PublisherElsevier Ltd
SubjectBroiler chicks
Immunotoxicity
In-vivo modification
Ochratoxin A
Trichosporon mycotoxinivoran
TitleImpact of dietary Trichosporon mycotoxinivorans on ochratoxin A induced immunotoxicity; In vivo study
TypeArticle
Volume Number132
dc.accessType Abstract Only


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