Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer
| Author | Tkac J. |
| Author | Gajdosova V. |
| Author | Hroncekova S. |
| Author | Bertok T. |
| Author | Hires M. |
| Author | Jane E. |
| Author | Lorencova L. |
| Author | Kasak P. |
| Available date | 2020-04-09T12:27:28Z |
| Publication Date | 2019 |
| Publication Name | Interface Focus |
| Resource | Scopus |
| ISSN | 20428898 |
| Abstract | The initial part of this review details the controversy behind the use of a serological level of prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel biomarkers are in demand for PCa diagnostics, outperforming traditional PSA tests. The review provides a detailed and comprehensive summary that PSA glycoprofiling can effectively solve this problem, thereby considerably reducing the number of unnecessary biopsies. In addition, PSA glycoprofiling can serve as a prognostic PCa biomarker to identify PCa patients with an aggressive form of PCa, avoiding unnecessary further treatments which are significantly life altering (incontinence or impotence). |
| Sponsor | acknowledge the support received from the ERC Proof of Concept grant (no. 825586) and from the Innovative Training Network (no. 813120). This publication is the result of the project implementation: Centre for materials, layers and systems for applications and chemical processes under extreme conditions stage I, ITMS no.: 26240120007, supported by the ERDF. |
| Language | en |
| Publisher | Royal Society Publishing |
| Subject | Biomarkers Diagnostics Glycans Lectins Prostate cancer Prostate-specific antigen |
| Type | Article Review |
| Issue Number | 2 |
| Volume Number | 9 |
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Center for Advanced Materials Research [1378 items ]