CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program
| المؤلف | Thaventhiran T. |
| المؤلف | Wong W. |
| المؤلف | Alghanem A.F. |
| المؤلف | Alhumeed N. |
| المؤلف | Aljasir M.A. |
| المؤلف | Ramsey S. |
| المؤلف | Sethu S. |
| المؤلف | Yeang H.X.A. |
| المؤلف | Chadwick A.E. |
| المؤلف | Cross M. |
| المؤلف | Webb S.D. |
| المؤلف | Djouhri L. |
| المؤلف | Ball C. |
| المؤلف | Stebbings R. |
| المؤلف | Sathish J.G. |
| تاريخ الإتاحة | 2020-04-16T06:56:46Z |
| تاريخ النشر | 2019 |
| اسم المنشور | Monoclonal Antibodies in Immunodiagnosis and Immunotherapy |
| المصدر | Scopus |
| الرقم المعياري الدولي للكتاب | 21679436 |
| الملخص | CD28 superagonist (CD28SA), a therapeutic immunomodulatory monoclonal antibody triggered rapid and exaggerated activation of CD4+ effector memory T cells (TEMs) in humans with unwanted serious adverse effects. It is well known that distinct metabolic programs determine the fate and responses of immune cells. In this study, we show that human CD4+ TEMs stimulated with CD28SA adopt a metabolic program similar to those of tumor cells with enhanced glucose utilization, lipid biosynthesis, and proliferation in hypoxic conditions. Identification of metabolic profiles underlying hyperactive T cell activation would provide a platform to test safety of immunostimulatory antibodies. |
| راعي المشروع | This work was supported by funding from the Medical Research Council, United Kingdom (G1000397-2/1). |
| اللغة | en |
| الناشر | Mary Ann Liebert Inc. |
| الموضوع | CD28 superagonist CD4+ effector memory T cells glycolysis lipogenesis oxidative phosphorylation |
| النوع | Article |
| الصفحات | 60-69 |
| رقم العدد | 2 |
| رقم المجلد | 38 |
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