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AuthorAlbinali, Kholoud E.
AuthorZagho, Moustafa M.
AuthorDeng, Yonghui
AuthorElzatahry, Ahmed A.
Available date2020-06-23T20:45:39Z
Publication Date2019
Publication NameInternational Journal of Nanomedicine
ResourceScopus
ISSN11769114
URIhttp://dx.doi.org/10.2147/IJN.S193981
URIhttp://hdl.handle.net/10576/15092
AbstractMagnetic core–shell nanocarriers have been attracting growing interest owing to their physicochemical and structural properties. The main principles of magnetic nanoparticles (MNPs) are localized treatment and stability under the effect of external magnetic fields. Furthermore, these MNPs can be coated or functionalized to gain a responsive property to a specific trigger, such as pH, heat, or even enzymes. Current investigations have been focused on the employment of this concept in cancer therapies. The evaluation of magnetic core–shell materials includes their magnetization properties, toxicity, and efficacy in drug uptake and release. This review discusses some categories of magnetic core–shell drug carriers based on Fe2O3 and Fe3O4 as the core, and different shells such as poly(lactic-co-glycolic acid), poly(vinylpyrrolidone), chitosan, silica, calcium silicate, metal, and lipids. In addition, the review addresses their recent potential applications for cancer treatment.
SponsorThe authors would like to acknowledge Qatar University for funding the project: GCC Co-Fund Program Grant #GCC-2017-001 and student grant QUST-1-CAS-2019-36. The publication of this article was funded by the Qatar National Library.
Languageen
PublisherDove Medical Press Ltd.
SubjectActive targeting
Controlled release
Core
Drug carriers
Magnetic
Mesoporous
Passive targeting
Shell
Targeted cancer treatment
TitleA perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
TypeArticle Review
Pagination1707-1723
Volume Number14
dc.accessType Open Access


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