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المؤلفSundarabharathi, Lakshmanaperumal
المؤلفChinnaswamy, Mahendran
المؤلفPonnamma, Deepalekshmi
المؤلفParangusan, Hemalatha
المؤلفAl-Maadeed, Mariam Al Ali
تاريخ الإتاحة2020-06-23T20:45:41Z
تاريخ النشر2019
اسم المنشورJournal of the American Ceramic Society
المصدرScopus
الرقم المعياري الدولي للكتاب27820
معرّف المصادر الموحدhttp://dx.doi.org/10.1111/jace.15866
معرّف المصادر الموحدhttp://hdl.handle.net/10576/15127
الملخصDual doped calcium apatite has been widely focused as it enhances the osteoconductive property for the possible applications in orthopedic and dental implants. In this work, we investigate the antimicrobial and bioactive properties of cerium/strontium (Ce3+/Sr2+) co‐substituted hydroxyapatite (HA ) nanoparticles synthesized by sol‐gel assisted precipitation method. The structure, morphology, functional groups, photoluminescence, and thermal stability of the developed systems are examined. The comparative studies performed among the pure HA , Sr2+, and Ce3+‐substituted HA nanoparticles illustrate higher antibacterial activity with lowered apatite‐forming ability and biocompatibility for the Ce3+‐substituted HA . However, the Ce3+/Sr2+co‐substituted HA exhibits better biocompatibility, apatite‐forming ability, and good antimicrobial properties. Sr2+ ion inclusion leads to better biological properties and compromise the cytotoxic nature of the Ce3+‐HA . In addition, the Ce3+/Sr2+‐HA nanoparticles prevent thermal decomposition up to 700°C, pointing also toward the possibility of this co‐substituted HA in bone implant applications.
راعي المشروعThis work has been funded by the University Grants Commission (UGC) SERO, Hyderabad, India (No. F MRF-6819/16) (SERO/UGC). The author Dr. C. Mahendran is grateful for the financial support.
اللغةen
الناشرBlackwell Publishing Inc.
الموضوعbioactivity
biocompatibility
hydroxyapatite
live cell imaging
Sol-gel
العنوانInvestigation of antimicrobial properties and in-vitro bioactivity of Ce3+-Sr2+dual-substituted nano hydroxyapatites
النوعArticle
الصفحات144-157
رقم العدد1
رقم المجلد102
dc.accessType Abstract Only


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