Show simple item record

AuthorRehman, Syed Raza ur
AuthorAugustine, Robin
AuthorZahid, Alap Ali
AuthorAhmed, Rashid
AuthorHasan, Anwarul
Available date2020-07-16T20:11:03Z
Publication Date2019
Publication NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
ResourceScopus
Identifierhttp://dx.doi.org/10.2147/IJN.S218120
URIhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065391255&partnerID=40&md5=b4fa3c43b00ee0c13bb3e0013a003049
URIhttp://hdl.handle.net/10576/15247
AbstractStatement of Purpose: Non-healing or slow healing of chronic wounds is among the serious complications of diabetes. Decrease in blood supply along with oxygen, nutrients and growth factors leads to reduced proliferation and migration of fibroblasts and keratinocyte cells as well as decrease in angiogenesis and collagen deposition in diabetic wounds [1]. Therefore, designing a wound dressing patch using a biodegradable material which can provide a sustained release/delivery of some angiogenic factor and promote rapid development of blood vessels will be highly beneficial for enhanced diabetic wound healing. Multiple evidences from both in-vitro and in-vivo studies have shown that graphene oxide (GO) and reduced graphene oxide promote wound healing by promoting proliferation and migration of fibroblasts and keratinocytes cells. In addition, rGO possesses pre-angiogenic property. Gelatin methacrylate (GelMA) based hydrogels display excellent hydrophilic properties due to the presence of hydrophilic amido, amino, carboxyl and hydroxyl groups in the polymer chains, which gives them highly porous, soft and flexible structure. In the current work, we have developed a reduced graphene oxide incorporated GelMA hydrogel dressing to improve wound healing by increasing proliferation and migration of cells as well as promoting formation of new blood vessels for increased supply of nutrients, oxygen and growth factors to wound area.
Languageen
PublisherSociety for Biomaterials
Subjectgraphene oxide (GO)
Gelatin methacrylate (GelMA)
TitleReduced graphene oxide impregnated gelma hydrogel promotes angiogenic activity in chick embryo model
TypeConference Paper
Volume Number40
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record