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المؤلفAlsaied, Amer
المؤلفIslam, Nazmul
المؤلفThalib, Lukman
تاريخ الإتاحة2020-07-19T11:13:50Z
تاريخ النشر2020-07-13
اسم المنشورBMC Pediatrics
المعرّفhttp://dx.doi.org/10.1186/s12887-020-02231-5
الاقتباسAlsaied, A., Islam, N. & Thalib, L. Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis. BMC Pediatr 20, 344 (2020). https://doi.org/10.1186/s12887-020-02231-5
المعرّف344
معرّف المصادر الموحدhttp://hdl.handle.net/10576/15292
الملخصBackground: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW). Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Incidence were pooled using Random Effect Models (REM), in the presence of substantial heterogeneity. Additional, bias adjusted Quality Effect Models (QEM) were used to get sensitivity estimates. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias. Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The number of neonate included in these studies was 574,692. Of this 39,965 developed NEC. There were substantial heterogeneity between studies (I2 = 100%). The pooled estimate of NEC based on REM was 7.0% (95% CI: 6.0-8.0%). QEM based estimate (6.0%; 95% CI: 4.0-9.0%) were also similar. Funnel plots showed no evidence of publication bias. Although, NEC estimates are similar across various regions, some variation between high and low income countries were noted. Meta regression findings showed a statistically significant increase of NEC over time, quantified by the publication year. Conclusion: Seven out of 100 of all VLBW infants in NICU are likely to develop NEC. However, there were considerable heterogeneity between studies. High quality studies assessing incidence of NEC along with associated risk factors are warranted. Keywords: Incidence; Meta-analysis; Necrotizing Enterocolitis; Systematic review.
اللغةen
الناشرBMC
الموضوعIncidence
Meta-analysis
Necrotizing Enterocolitis
Systematic review
العنوانGlobal incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis
النوعArticle
رقم المجلد20
ESSN1471-2431
dc.accessType Open Access


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