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AuthorBouallagui, Zouhaier
AuthorMahmoudi, Asma
AuthorMaalej, Amina
AuthorHadrich, Fatma
AuthorIsoda, Hiroko
AuthorSayadi, Sami
Available date2020-08-18T08:34:15Z
Publication Date2019
Publication NameAnti-Cancer Agents in Medicinal Chemistry
ResourceScopus
ISSN18715206
URIhttp://dx.doi.org/10.2174/1871520619666190416101622
URIhttp://hdl.handle.net/10576/15558
AbstractAims: This study was designed to investigate the phytochemical profile and the cytotoxic activities of the eco-friendly extracts of olive leaves from Chemlali cultivar. Materials and Methods: The Phenolic composition of olive leaves extracts, the antioxidant activity and the cytotoxic effects against MCF-7 and HepG2 cells were determined. Results: Olive leaves extracts showed relevant total polyphenols contents. Oleuropein was the major detected phenolic compound reaching a concentration of 16.9 mg/ml. The antioxidant potential of the studied extracts varied from 23.7 to 46.5mM Trolox equivalents as revealed by DPPH and ABTS assays. Cytotoxicity experiments showed similar trends for both HepG2 and MCF-7 cells with the infusion extract being the most active. Conclusion: This study denotes that olive leaves may have great potential as endless bioresource of valuable bioactive compounds which may have a wide application. - 2019 Bentham Science Publishers.
SponsorThis work was supported by the Tunisian Ministery of Higher Education and Scientific Research under the contract program for Laboratory of Environmental Bioprocesses at Centre of Biotechnology of Sfax. This work was also partially supported by the JICA/JST Science and Technology Research Partnership for Sustainable Development (SATREPS) Project (A6A24087): �Valorization of Bio-resources in Semi-arid and Arid Land for Regional Development''.
Languageen
PublisherBentham Science Publishers
SubjectBioactivities
Leaves
Olea europaea
Phytochemical profile
Polyphenols
�Chemlali'' cultivar
TitleContribution of major polyphenols to the antioxidant profile and cytotoxic activity of olive leaves
TypeArticle
Pagination1651-1657
Issue Number13
Volume Number19
dc.accessType Abstract Only


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