عرض بسيط للتسجيلة

المؤلفZaqout, Sami
المؤلفBecker, Lena-Luise
المؤلفMustafa, Ayman
المؤلفKramer, Nadine
المؤلفStrauss, Ulf
المؤلفKaindl, Angela M.
تاريخ الإتاحة2020-10-26T08:49:52Z
تاريخ النشر2020
اسم المنشورQatar University Annual Research an Exhibition 2020 (quarfe)
الاقتباسZaqout S., Becker L.L., Mustafa A., Krsmer N., Strauss U., Kaindl A.M., "Role of Cdk5rap2 in neocortical inhibition and excitation balance", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 2020, https://doi.org/10.29117/quarfe.2020.0117
معرّف المصادر الموحدhttps://doi.org/10.29117/quarfe.2020.0117
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16701
الملخصAutosomal recessive primary microcephaly type 3 (MCPH3) is characterized by congenital microcephaly and intellectual disability. Further features include hyperactivity and seizures. The disease is caused by biallelic mutations in the Cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2. In the mouse, Cdk5rap2 mutations similarly result in reduced brain size and a strikingly thin neocortex already at early stages of neurogenesis that persists through adulthood. The microcephaly phenotype in MCPH arises from a neural stem cell proliferation defect. Here, we report a novel role for Cdk5rap2 in the regulation of dendritic development and synaptogenesis of neocortical layer 2/3 pyramidal neurons using a combined morphological and electrophysiological approach.
اللغةen
الناشرQatar University Press
الموضوعCdk5rap2
Microcephaly
Neuronal differentiation
Synaptic transmission
Dendritic morphogenesis
العنوانRole of Cdk5rap2 in neocortical inhibition and excitation balance
النوعPoster
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة