Show simple item record

AuthorAlam, Mohammed
Available date2020-10-26T08:49:53Z
Publication Date2020
Publication NameQatar University Annual Research an Exhibition 2020 (quarfe)
CitationAlam M.,"A Decision Analytical Model Investigating Cost-Effectiveness of Erlotinib", Qatar University Annual Research Forum and Exhibition (QUARFE 2020), Doha, 28 October 2020, DOI: https://doi.org/10.29117/quarfe.2020.0145
URIhttps://doi.org/10.29117/quarfe.2020.0145
URIhttp://hdl.handle.net/10576/16728
AbstractBackground: A decision analytical model investigating cost-effectiveness of Erlotinib was submitted to the UK NICE (National Institute for Health and Care Excellence), which was not based on actual health-state transition probabilities, leading to structural uncertainty in the model. The study adopted a Markov state-transition model for investigating the cost-effectiveness of Erlotinib versus Best Supportive Care (BSC) as a maintenance therapy for patients with non-small cell lung cancer (NSCLC). Methods: Unlike manufacturer submission (MS), the Markov model was governed by transition probabilities, and allowed a negative post-progression survival (PPS) estimate to appear in later cycle. Using published summary survival data, the study employs three fixed- and time-varying approaches to estimate state transition probabilities that are used in a restructured model. Results: Post-progression probabilities and probabilities of death for Erlotinib were different than fixed-transition approaches. The best fitting curves are achieved for both PPS and probability of death across the time for which data were available, but the curves start diverging towards the end of this period. The Markov model which extrapolates the curves forward in time suggests that this difference between a time-varying and fixed-transition becomes even greater. Our models produce an ICER of 54k - 66k per QALY gain, which is comparable to an ICER presented in the MS (55k/QALY gain). Conclusions: Results from restructured Markov models show robust cost-effectiveness results for Erlotinib vs BSC. Although these are comparable to manufacturer submissions, in terms of magnitude they vary, and which are crucial for interventions falling near a threshold value. The study will further explore the cost-effectiveness of therapies for NSCLC in Qatar.
Languageen
PublisherQatar University Press
SubjectNon-Small Cell Lung Cancer
Decision Model
Cost-Effectiveness.
TitleA Decision Analytical Model Investigating Cost-Effectiveness of Erlotinib
TypePoster
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record