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AuthorWei, Jing
AuthorRen, Yuan
AuthorLuo, Wei
AuthorSun, Zhenkun
AuthorCheng, Xiaowei
AuthorLi, Yuhui
AuthorDeng, Yonghui
AuthorElzatahry, Ahmed A.
AuthorAl-Dahyan, Daifallah
AuthorZhao, Dongyuan
Available date2020-11-26T11:21:09Z
Publication Date2017
Publication NameChemistry of Materials
ResourceScopus
URIhttp://dx.doi.org/10.1021/acs.chemmater.6b05032
URIhttp://hdl.handle.net/10576/17101
AbstractAlumina has recently turned out to be effective in enrichment of biomacrolecules like phosphopeptides due to its good affinity to phosphor groups. Ordered mesoporous alumina (OMA) materials with high surface areas, regular porous structures, and large pore size are an ideal absorbent for the enrichment of phosphopeptides. Herein, a ligand-assisted solvent evaporation induced coassembly route is developed to synthesize OMA materials with an ultralarge pore size (16.0-18.9 nm) using a high-molecular-weight poly(ethylene oxide)-b-polystyrene (PEO-b-PS) as a soft template, aluminum acetylacetonate as a precursor, and tetrahydrofuran as a solvent. The obtained ordered mesoporous alumina shows high surface area (114-197 m2/g), large pore volume (0.16-0.34 cm3/g), and high thermal stability (up to 900 �C). The OMA materials show crystalline ?-Al2O3 frameworks with crystal size of ?11 nm after calcination at 900 �C in air. Because of their high surface area, ultralarge pore size, and rich Lewis acid sites, the obtained OMA materials are demonstrated to be an excellent bioabsorbent in enriching phosphopeptides selectively from protein digestions with ultralow concentrations (2 ? 10-9 M), even from more complex samples from human serum.
SponsorThis work was supported by State Key Basic Research Program of PRC (2013CB934104), NSF of China (51372041, 51422202, 21673048, 51402049, 51432004, 21210004, and U1463206), the Shanghai Committee of Science and Technology, China (14ZR1400600, 14JC1400700, 15ZR1402000), Shanghai Leading Academic Discipline Project (B108), the ?Shu Guang? Project (13SG02) supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation, National Youth Topnotch Talent Support Program of China, Shanghai Pujiang Program, China (No. 16PJ1401100), the Innovation Program of Shanghai Municipal Education Commission (13ZZ004), Program for New Century Excellent Talents in University, "Young Talent Support Plan" of Xi?an Jiaotong University, and the Qatar University and Princess Nourah bint Abdulrahman University under GCC Co-Fund Program Grant GCC-2017-001. The authors extend their appreciation to the International Scientific Partnership Program ISPP at King Saud University for funding this research work through ISPP# 0018.
Languageen
PublisherAmerican Chemical Society
TitleOrdered Mesoporous Alumina with Ultra-Large Pores as an Efficient Absorbent for Selective Bioenrichment
TypeArticle
Pagination2211-2217
Issue Number5
Volume Number29
dc.accessType Abstract Only


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