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AuthorElazazy, Marwa S.
AuthorGanesh, K.
AuthorSivakumar, V.
AuthorHuessein, Yasser H. A.
Available date2021-06-24T06:47:08Z
Publication Date2016
Publication NameRSC Advances
ResourceScopus
ISSN20462069
URIhttp://dx.doi.org/10.1039/c6ra10533e
URIhttp://hdl.handle.net/10576/20835
AbstractIn the current paper, and for the first time, spectrophotometry coupled with a set of factorial designs was executed as a new tool for investigating the interaction between p-synephrine (p-SY) and p-chloranil (p-CHL). Two types of complexes were observed as a result of this interaction. The first complex, an intermolecular charge transfer complex, was measured at 452 nm, while the second, an intramolecular charge transfer complex, was measured at 536 nm. A chemometric assisted screening and optimization of the absorbance at the two wavelengths was scrutinized. As a screening procedure, a 2-level full factorial design (2k-FFD) was employed. Method variables, such as reaction temperature, heating time, reagent volume, and solvent type were considered and the response was measured at the individual wavelengths. With the help of Pareto analysis, and ANOVA testing (following a response transformation employing Box-Cox treatment), variables ascertained to be significant (p < 0.05) were selected. Significant factors were carefully adjusted, exploiting a response surface methodology (RSM) with a face-centered central composite design (FCCCD). Afterwards, and with the help of the overlaid contour plots, and Derringer's desirability function, the multiple responses (Y1 and Y2) were simultaneously optimized and consolidated into a unified performance characteristic. The proposed model denoted the efficacy of experimental designs in adjusting the reaction variables and maximizing the output. Scott's plot, and other models were used to determine the formation constant of a 1:1 complex. Validation of the proposed procedure was performed using ANOVA. Linearity, detection and quantification limits as well as accuracy, within-day and intermediate precisions have been assessed following ICH guidelines for evaluation of analytical procedures. 2016 The Royal Society of Chemistry.
Languageen
PublisherRoyal Society of Chemistry
SubjectAnalysis of variance (ANOVA)
Charge transfer
Chemical reactions
Design of experiments
Statistics
Central composite designs
Derringer's desirability function
Detection and quantification limit
Intermolecular charge transfer
Intra-molecular charge transfer
Multiple response optimization
Performance characteristics
Response surface methodology
Design
TitleInteraction of: P -synephrine with p -chloranil: Experimental design and multiple response optimization
TypeArticle
Pagination64967-64976
Issue Number69
Volume Number6
dc.accessType Open Access


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