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AuthorSalih, Kifah S. M.
AuthorAl-Salihi, Suhad A. A.
AuthorBull, Ian D.
AuthorAl-Salhi, Raghad
AuthorGates, Paul J.
AuthorSalih, Kifah S. M.
AuthorBailey, Andy M.
AuthorFoster, Gary D.
Available date2022-01-30T06:42:28Z
Publication Date2021-05-24
Publication NameFrontiers in Bioengineering and Biotechnology
Identifierhttp://dx.doi.org/10.3389/fbioe.2021.567384
CitationFurther Biochemical Profiling of Hypholoma fasciculare Metabolome Reveals Its Chemogenetic Diversity Suhad A. A. Al-Salihi, Ian D. Bull, Raghad Al-Salhi, Paul J. Gates, Kifah S. M. Salih, Andy M. Bailey, Gary D. Foster Front Bioeng Biotechnol. 2021; 9: 567384. Published online 2021 May 24. doi: 10.3389/fbioe.2021.567384 PMCID: PMC8181146
Identifier567384
URIhttp://hdl.handle.net/10576/26049
AbstractNatural products with novel chemistry are urgently needed to battle the continued increase in microbial drug resistance. Mushroom-forming fungi are underutilized as a source of novel antibiotics in the literature due to their challenging culture preparation and genetic intractability. However, modern fungal molecular and synthetic biology tools have renewed interest in exploring mushroom fungi for novel therapeutic agents. The aims of this study were to investigate the secondary metabolites of nine basidiomycetes, screen their biological and chemical properties, and then investigate the genetic pathways associated with their production. Of the nine fungi selected, was revealed to be a highly active antagonistic species, with antimicrobial activity against three different microorganisms: , , and . Genomic comparisons and chromatographic studies were employed to characterize more than 15 biosynthetic gene clusters and resulted in the identification of 3,5-dichloromethoxy benzoic acid as a potential antibacterial compound. The biosynthetic gene cluster for this product is also predicted. This study reinforces the potential of mushroom-forming fungi as an underexplored reservoir of bioactive natural products. Access to genomic data, and chemical-based frameworks, will assist the development and application of novel molecules with applications in both the pharmaceutical and agrochemical industries.
Languageen
PublisherPMC
SubjectHypholoma fasciculare
genome
metabolome
terpene
biosynthetic gene cluster
TitleFurther Biochemical Profiling of Metabolome Reveals Its Chemogenetic Diversity
TypeArticle
Volume Number9
dc.accessType Open Access


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