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AuthorMrlík, Miroslav
AuthorŠpírek, Mário
AuthorAl-Khori, Jassim
AuthorAhmad, Ali Abdulrahman
AuthorMosnaček, Jaroslav
AuthorAlMaadeed, Mariam AlAli
AuthorKasák, Peter
Available date2022-02-27T09:30:35Z
Publication Date2020
Publication NameArabian Journal of Chemistry
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.arabjc.2017.03.009
URIhttp://hdl.handle.net/10576/27465
AbstractIn the present study, the sulfobetaine-based copolymer bearing a dopamine functionality showed gel formation adjusted by the application of metal salts for gelation and various values of pH. Normally, the liquid-like solution of the sulfobetaine-based copolymer and metal cross-linkers is transformed to a gel-like state upon increasing the pH values in the presence of Fe3+ and Ti3+. Metal-induced coordination is reversible by means of the application of EDTA as a chelating agent. In the case of Ag+ ions, the gel is formed through a redox process accompanied with the oxidative coupling of the dopamine moieties and Ag0 particle formation. Mussel-mimicking and metal-dependent viscoelastic properties were observed for Fe3+, Ti3+, and Ag+ cross-linking agents, with additionally enhanced self-healing behavior in comparison with the covalently cross-linked IO4 ? analogues. Antibacterial properties can be achieved both in solution and on the surface using the proper concentration of Ag+ ions used for gelation; thus, a tunable amount of the Ag0 particles are formed in the hydrogel. The cytotoxicity was elucidated by the both MTT assay on the NIH/3T3 fibroblast cell line and direct contact method using human dermal fibroblast cell (F121) and shows the non-toxic character of the synthesized copolymer.
SponsorP.K. gratefully acknowledge Qatar University internal grant QUUG-CAM-2017-1. This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic ? Program NPU I (LO1504). This work was also supported by the Maersk Oil R&TC Qatar project. This work was also made possible by NPRP grant # 9 ? 219-2-105 from the Qatar National Research Fund (A Member of The Qatar Foundation). The finding achieved herein is solely the responsibility of the authors.
Languageen
PublisherElsevier B.V.
SubjectAmines
Cell culture
Chelation
Crosslinking
Fibroblasts
Gelation
Hydrogels
Molluscs
Neurophysiology
Self-healing materials
Viscoelasticity
Antibacterial
Antibacterial properties
Covalently cross-linked
Human dermal fibroblasts
Metal coordination
Polysulfobetaines
Self-healing
Viscoelastic properties
Metals
TitleMussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability
TypeArticle
Pagination193-204
Issue Number1
Volume Number13
dc.accessType Open Access


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