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AuthorLiu, Qi
AuthorWen, Qiaorui
AuthorLv, Jun
AuthorShi, Zumin
AuthorGuo, Yu
AuthorPei, Pei
AuthorDu, Huaidong
AuthorYang, Ling
AuthorChen, Yiping
AuthorZhang, Xiaofang
AuthorSchmidt, Dan
AuthorSansome, Sam
AuthorChen, Junshi
AuthorYu, Canqing
AuthorChen, Zhengming
AuthorLi, Liming
Available date2022-03-27T05:22:39Z
Publication Date2022-03-01
Publication NameNutrients
Identifierhttp://dx.doi.org/10.3390/nu14050980
CitationLiu, Q.; Wen, Q.; Lv, J.; Shi, Z.; Guo, Y.; Pei, P.; Du, H.; Yang, L.; Chen, Y.; Zhang, X.; Schmidt, D.; Sansome, S.; Chen, J.; Yu, C.; Chen, Z.; Li, L.; on behalf of the China Kadoorie Biobank Collaborative Group. The Prospective Associations of Lipid Metabolism-Related Dietary Patterns with the Risk of Diabetes in Chinese Adults. Nutrients 2022, 14, 980. https://doi.org/10.3390/nu14050980
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85125198528&origin=inward
URIhttp://hdl.handle.net/10576/29017
AbstractBackground: This study aimed to identify lipid metabolism-related dietary patterns with reduced rank regression (RRR) among Chinese adults and examine their associations with incident diabetes. Methods: We derived lipid metabolism-related dietary patterns using an RRR with 21 food groups as predictors as well as total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, body mass index (BMI), and waist circumference from the responses of 17,318 participants from the second resurvey of the China Kadoorie Biobank (CKB). The dietary scores were calculated for the entire cohort. We followed up 479,207 participants for diabetes incidence from the baseline and used multivariable Cox regression models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Two lipid metabolism-related dietary patterns were extracted. The dietary pattern—characterized by high intakes of fish, poultry, and other staples as well as fresh fruit and vegetables—was correlated with a higher BMI, waist circumference, and LDL cholesterol. Participants in the highest quintile (Q5) had a 44% increased risk of diabetes incidence when compared with those in the lowest quintile (Q1) (HR = 1.44; 95% CI: 1.31–1.59). Conclusions: A dietary pattern characterized by high intakes of both animal and plant foods was related to obesity and dyslipidemia and could increase the risk of diabetes incidence.
SponsorThis research was supported by the National Natural Science Foundation of China (81973125) and the National Key Research and Development Program of China (2016YFC0900500, 2016YFC0900501, 2016YFC0900504). The CKB baseline survey and the first resurvey were supported by a grant from the Kadoorie Charitable Foundation in Hong Kong. The long-term follow-up was supported by a grant (2016YFC1303904) from the National Key R&D Program of China, the National Natural Science Foundation of China (81390540, 81390541, 81390544), and the Chinese Ministry of Science and Technology (2011BAI09B01). The funders had no role in the study design, data collection, data analysis and interpretation, writing of the report, or the decision to submit the article for publication.
Languageen
PublisherMDPI
SubjectDiabetes
Dietary patterns
Lipid metabolism
Reduced rank regression
TitleThe Prospective Associations of Lipid Metabolism-Related Dietary Patterns with the Risk of Diabetes in Chinese Adults
TypeArticle
Issue Number5
Volume Number14
ESSN2072-6643
dc.accessType Open Access


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