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AuthorRiyaz, Najamus Sahar
AuthorBadran, Ismail
Available date2022-04-04T08:25:30Z
Publication Date2022-04-04
Publication NameJournal of Thermal Analysis and Calorimetry
Identifierhttp://dx.doi.org/10.1007/s10973-022-11304-9
CitationRiyaz, N.S., Badran, I. The catalytic thermo-oxidative decomposition of glimepiride using the isoconversional method. J Therm Anal Calorim (2022). https://doi.org/10.1007/s10973-022-11304-9
ISSN1388-6150
URIhttp://hdl.handle.net/10576/29294
AbstractApplying the isoconversional method to data obtained from thermogravimetric analysis (TGA) can provide vital kinetic information. In this work, the thermal decomposition and oxidation of the antidiabetic drug glimepiride is analyzed in the presence of N2 and O2. The study was done with and without metal oxide catalysts to explore their potential application in solid wastewater upgrading. The analysis was conducted using thermogravimetric analysis. The isoconversional methods of Kissinger–Akahira–Sunose and Friedman were used to estimate the effective activation energies as a function of the extent of conversion (α). Density functional calculations were used to estimate the bond dissociation energies in glimepiride. The Ea values obtained from the Friedman method and the DFT calculations indicate an initial S–N bond breaking in glimepiride. The pre-exponential factor (A) and the kinetic triplet (ΔH‡, ΔS‡, and ΔG‡) are also discussed. When glimepiride oxidation was studied in the presence of the metal oxides, the catalyst activity was found to follow the order
SponsorOpen Access funding provided by the Qatar National Library. This research was funded through a Qatar University student grant number QUST-1-CAS-2020–3.
Languageen
PublisherSpringer
SubjectPharmaceutical
Thermogravimetric analysis
Catalysts
Isoconversional
Adsorption
Oxidation
TitleThe catalytic thermo-oxidative decomposition of glimepiride using the isoconversional method
TypeArticle
ESSN1588-2926
dc.accessType Open Access


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