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المؤلفAugustine R.
المؤلفS A.
المؤلفNayeem A.
المؤلفSalam S.A.
المؤلفAugustine P.
المؤلفDan P.
المؤلفMaureira P.
المؤلفMraiche F.
المؤلفGentile C.
المؤلفHansbro P.M.
المؤلفMcClements L.
المؤلفHasan, Anwarul
تاريخ الإتاحة2022-05-21T10:18:25Z
تاريخ النشر2022
اسم المنشورChemico-Biological Interactions
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.cbi.2021.109738
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31249
الملخصThe rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID?19), has had a dramatic negative impact on public health and economies worldwide. Recent studies on COVID-19 complications and mortality rates suggest that there is a higher prevalence in cardiovascular diseases (CVD) patients. Past investigations on the associations between pre-existing CVDs and susceptibility to coronavirus infections including SARS-CoV and the Middle East Respiratory Syndrome coronavirus (MERS-CoV), have demonstrated similar results. However, the underlying mechanisms are poorly understood. This has impeded adequate risk stratification and treatment strategies for CVD patients with SARS-CoV-2 infections. Generally, dysregulation of the expression of angiotensin?converting enzyme (ACE) and the counter regulator, angiotensin?converting enzyme 2 (ACE2) is a hallmark of cardiovascular risk and CVD. ACE2 is the main host receptor for SARS-CoV-2. Although further studies are required, dysfunction of ACE2 after virus binding and dysregulation of the renin-angiotensin-aldosterone system (RAAS) signaling may worsen the outcomes of people affected by COVID-19 and with preexisting CVD. Here, we review the current knowledge and outline the gaps related to the relationship between CVD and COVID-19 with a focus on the RAAS. Improved understanding of the mechanisms regulating viral entry and the role of RAAS may direct future research with the potential to improve the prevention and management of COVID-19.
اللغةen
الناشرElsevier Ireland Ltd
الموضوعACE2
Cardiovascular diseases
Coronavirus
COVID-19
RAAS
SARS-CoV-2
العنوانIncreased complications of COVID-19 in people with cardiovascular disease: Role of the renin-angiotensin-aldosterone system (RAAS) dysregulation
النوعArticle
رقم المجلد351
dc.accessType Open Access


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