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المؤلفAhmed R.
المؤلفAugustine R.
المؤلفValera E.
المؤلفGanguli A.
المؤلفMesaeli N.
المؤلفAhmad I.S.
المؤلفBashir R.
المؤلفHasan, Anwarul
تاريخ الإتاحة2022-05-21T10:18:25Z
تاريخ النشر2022
اسم المنشورBiochimica et Biophysica Acta - Reviews on Cancer
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.bbcan.2021.188663
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31250
الملخصSpatial mapping of heterogeneity in gene expression in cancer tissues can improve our understanding of cancers and help in the rapid detection of cancers with high accuracy and reliability. Significant advancements have been made in recent years in OMICS technologies, which possess the strong potential to be applied in the spatial mapping of biopsy tissue samples and their molecular profiling to a single-cell level. The clinical application of OMICS technologies in spatial profiling of cancer tissues is also advancing. The current review presents recent advancements and prospects of applying OMICS technologies to the spatial mapping of various analytes in cancer tissues. We benchmark the current state of the art in the field to advance existing OMICS technologies for high throughput spatial profiling. The factors taken into consideration include spatial resolution, types of biomolecules, number of different biomolecules that can be detected from the same assay, labeled versus label-free approaches, and approximate time required for each assay. Further advancements are still needed for the widespread application of OMICs technologies in performing fast and high throughput spatial mapping of cancer tissues as well as their effective use in research and clinical applications.
اللغةen
الناشرElsevier B.V.
الموضوعDigital pathology
Mass spectrometry
Microarray technologies
OMICS technologies
Single cell RNA sequencing
Spatial profiling
Tumor tissues
العنوانSpatial mapping of cancer tissues by OMICS technologies
النوعArticle
رقم العدد1
رقم المجلد1877
dc.accessType Abstract Only


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