Show simple item record

AuthorAhmed R.
AuthorAugustine R.
AuthorValera E.
AuthorGanguli A.
AuthorMesaeli N.
AuthorAhmad I.S.
AuthorBashir R.
AuthorHasan, Anwarul
Available date2022-05-21T10:18:25Z
Publication Date2022
Publication NameBiochimica et Biophysica Acta - Reviews on Cancer
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.bbcan.2021.188663
URIhttp://hdl.handle.net/10576/31250
AbstractSpatial mapping of heterogeneity in gene expression in cancer tissues can improve our understanding of cancers and help in the rapid detection of cancers with high accuracy and reliability. Significant advancements have been made in recent years in OMICS technologies, which possess the strong potential to be applied in the spatial mapping of biopsy tissue samples and their molecular profiling to a single-cell level. The clinical application of OMICS technologies in spatial profiling of cancer tissues is also advancing. The current review presents recent advancements and prospects of applying OMICS technologies to the spatial mapping of various analytes in cancer tissues. We benchmark the current state of the art in the field to advance existing OMICS technologies for high throughput spatial profiling. The factors taken into consideration include spatial resolution, types of biomolecules, number of different biomolecules that can be detected from the same assay, labeled versus label-free approaches, and approximate time required for each assay. Further advancements are still needed for the widespread application of OMICs technologies in performing fast and high throughput spatial mapping of cancer tissues as well as their effective use in research and clinical applications.
Languageen
PublisherElsevier B.V.
SubjectDigital pathology
Mass spectrometry
Microarray technologies
OMICS technologies
Single cell RNA sequencing
Spatial profiling
Tumor tissues
TitleSpatial mapping of cancer tissues by OMICS technologies
TypeArticle
Issue Number1
Volume Number1877
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record