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AuthorSiebert, Leonard
AuthorLuna-Cerón, Eder
AuthorGarcía-Rivera, Luis Enrique
AuthorOh, Junsung
AuthorJang, JunHwee
AuthorRosas-Gómez, Diego A.
AuthorPérez-Gómez, Mitzi D.
AuthorMaschkowitz, Gregor
AuthorFickenscher, Helmut
AuthorOceguera-Cuevas, Daniela
AuthorHolguín-León, Carmen G.
AuthorByambaa, Batzaya
AuthorHussain, Mohammad A.
AuthorEnciso-Martínez, Eduardo
AuthorCho, Minsung
AuthorLee, Yuhan
AuthorSobahi, Nebras
AuthorHasan, Anwarul
AuthorOrgill, Dennis P.
AuthorMishra, Yogendra Kumar
AuthorAdelung, Rainer
AuthorLee, Eunjung
AuthorShin, Su Ryon
Available date2022-05-21T10:18:27Z
Publication Date2021
Publication NameAdvanced Functional Materials
ResourceScopus
Identifierhttp://dx.doi.org/10.1002/adfm.202007555
URIhttp://hdl.handle.net/10576/31273
URIhttp://dx.doi.org/10.1002/adfm.202007555
AbstractAdvanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light-triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t-ZnO) microparticles is developed. To achieve the smart release of VEGF, t-ZnO is modified by chemical treatment and activated through ultraviolet/visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t-ZnO concentrations. The t-ZnO-laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF-decorated t-ZnO-laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.
Languageen
PublisherJohn Wiley and Sons Inc
Subject3D printing
controlled release
hydrogel composites
photoactive
wound healing
zinc oxide tetrapod
TitleLight-Controlled Growth Factors Release on Tetrapodal ZnO-Incorporated 3D-Printed Hydrogels for Developing Smart Wound Scaffold
TypeArticle
Pagination153-170
Issue Number22
Volume Number31
dc.accessType Abstract Only


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