Show simple item record

AuthorKhan S.
AuthorSharifi M.
AuthorHasan, Anwarul
AuthorAttar F.
AuthorEdis Z.
AuthorBai Q.
AuthorDerakhshankhah H.
AuthorFalahati M.
Available date2022-05-21T10:18:27Z
Publication Date2021
Publication NameJournal of Advanced Research
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.jare.2020.12.001
URIhttp://hdl.handle.net/10576/31274
AbstractBackground: Heterocyclic compounds have always been used as a core portion in the development of anticancer drugs. However, there is a pressing need for developing inexpensive and simple alternatives to high-cost and complex chemical agents-based catalysts for large-scale production of heterocyclic compounds. Also, development of some smart platforms for cancer treatment based on nanoparticles (NPs) which facilitate Fenton reaction have been widely explored by different scientists. Magnetic NPs not only can serve as catalysts in the synthesis of heterocyclic compounds with potential anticancer properties, but also are widely used as smart agents in targeting cancer cells and inducing Fenton reactions. Aim of Review: Therefore, in this review we aim to present an updated summary of the reports related to the main clinical or basic application and research progress of magnetic NPs in cancer as well as their application in the synthesis of heterocyclic compounds as potential anticancer drugs. Afterwards, specific tumor microenvironment (TME)-responsive magnetic nanocatalysts for cancer treatment through triggering Fenton-like reactions were surveyed. Finally, some ignored factors in the design of magnetic nanocatalysts- triggered Fenton-like reaction, challenges and future perspective of magnetic nanocatalysts-assisted synthesis of heterocyclic compounds and selective cancer therapy were discussed. Key Scientific Concepts of Review: This review may pave the way for well-organized translation of magnetic nanocatalysts in cancer therapy from the bench to the bedside.
Languageen
PublisherElsevier B.V.
SubjectAnticancer drugs
Cancer therapy
Fenton reaction
Heterocyclic compounds
Magnetic nanocatalysts
TitleMagnetic nanocatalysts as multifunctional platforms in cancer therapy through the synthesis of anticancer drugs and facilitated Fenton reaction
TypeArticle
Volume Number30
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record