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AuthorPotyondy T.
AuthorUquillas J.A.
AuthorTebon P.J.
AuthorByambaa B.
AuthorHasan, Anwarul
AuthorTavafoghi M.
AuthorMary H.
AuthorAninwene G.E.
AuthorPountos I.
AuthorKhademhosseini A.
AuthorAshammakhi N.
Available date2022-05-21T10:18:27Z
Publication Date2021
Publication NameBiofabrication
ResourceScopus
Identifierhttp://dx.doi.org/10.1088/1758-5090/abc8de
URIhttp://hdl.handle.net/10576/31277
AbstractThe musculoskeletal system is essential for maintaining posture, protecting organs, facilitating locomotion, and regulating various cellular and metabolic functions. Injury to this system due to trauma or wear is common, and severe damage may require surgery to restore function and prevent further harm. Autografts are the current gold standard for the replacement of lost or damaged tissues. However, these grafts are constrained by limited supply and donor site morbidity. Allografts, xenografts, and alloplastic materials represent viable alternatives, but each of these methods also has its own problems and limitations. Technological advances in three-dimensional (3D) printing and its biomedical adaptation, 3D bioprinting, have the potential to provide viable, autologous tissue-like constructs that can be used to repair musculoskeletal defects. Though bioprinting is currently unable to develop mature, implantable tissues, it can pattern cells in 3D constructs with features facilitating maturation and vascularization. Further advances in the field may enable the manufacture of constructs that can mimic native tissues in complexity, spatial heterogeneity, and ultimately, clinical utility. This review studies the use of 3D bioprinting for engineering bone, cartilage, muscle, tendon, ligament, and their interface tissues. Additionally, the current limitations and challenges in the field are discussed and the prospects for future progress are highlighted.
Languageen
PublisherIOP Publishing Ltd
Subject3D bioprinting
bone
graft
musculoskeletal
tissue defects
tissue engineering
TitleRecent advances in 3D bioprinting of musculoskeletal tissues
TypeArticle
Issue Number2
Volume Number13
dc.accessType Abstract Only


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