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المؤلفJamshidi-adegani F.
المؤلفVakilian S.
المؤلفRehman N.U.
المؤلفAl-Broumi M.
المؤلفAl-kindi J.
المؤلفAlam K.
المؤلفMozafarinahavandi P.
المؤلفHasan, Anwarul
المؤلفAl-Riyami H.
المؤلفHussain J.
المؤلفWhite S.
المؤلفAl-Harrasi A.
المؤلفAl-Hashmi S.
تاريخ الإتاحة2022-05-21T10:18:30Z
تاريخ النشر2020
اسم المنشورMolecular Biology Reports
المصدرScopus
المعرّفhttp://dx.doi.org/10.1007/s11033-020-05632-y
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31305
الملخصAbstract: Among medicinal plants, Acridocarpus orientalis (AO) possesses a remarkable anti-cancer potential, possibly because of its anti-oxidant property. In this study, the leaf and stem extracts from AO were assessed to find the bioactive compound with selective anti-cancer properties. The MTT viability and live and dead assays revealed that around 80% and 98% of 4T1 cells survival were declined after 48�h incubation with leaf and stem extracts, respectively. The leaf extract increased stem cell proliferation by 20% whereas the stem extract inhibited around 22% of stem cells proliferation after 48�h treatment. The live and dead assay of MSCs confirmed that 40% of the MSCs died when treated with AO stem extract. On the other hand, there were no dead cells after two days of treatment with the leaf extract. Followed by the induction of cell cycle arrest in G0/G1-phase, the real-time PCR demonstrated apoptosis properties in 4T1 cells through overexpression of Bax and down-regulation of BCL2 genes. Interestingly, within the pure compounds isolated from AO leaf extract, Morin was responsible for the inhibition of 4T1 cells proliferation as well as MSCs expansion, predicting to play an essential role in the treatment of cancer. The promising�in vitro�anti-cancer and stem cell-inductive properties of morin isolated from AO extract may provide a great potential to produce selective herbal derived drugs. Graphic abstract: [Figure not available: see fulltext.]
اللغةen
الناشرSpringer
الموضوع4T1 cells
Acridocarpus orientalis
Breast cancer
Mesenchymal stem cells
Morine
Triterpenoids
العنوانSecondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation
النوعArticle
رقم العدد7
رقم المجلد47
dc.accessType Abstract Only


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