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AuthorAlam K.
AuthorIqbal M.
AuthorHasan, Anwarul
AuthorAl-Maskari N.
Available date2022-05-21T10:18:31Z
Publication Date2020
Publication NameJournal of Applied Biotechnology Reports
ResourceScopus
Identifierhttp://dx.doi.org/10.30491/jabr.2020.109994
URIhttp://hdl.handle.net/10576/31309
AbstractIntroduction: Biological hydrogels provide a conducive extracellular environment for encapsulating and growing cells and play an important role in regulating cell behavior. Mechanical and rheological properties of hydrogels can influence cell function, mechanotransduction and cellular behaviors such as growth, migration, adhesion, self-renewal, differentiation, morphology and fate. Determination of rheological properties of biogels is important for printing tissues by controlling physical properties and developing efficient drug delivery systems. The main purpose of the current study was to determine some important rheological properties of two well-known hydrogels (agarose and gelatin methacryloyl [GelMA]). Materials and Methods: Rheological properties of gel solutions with different concentrations were measured using oscillatory rheometry. Agarose gels of 1% and 2% (w/v) concentration were prepared in 100 mL de-ionized water. The GelMA solutions of 10% and 15% concentrations were prepared by dissolving dry GelMA in deionized water. Rheological measurements were performed using a rheometer with cone-plate geometry. Results: Both storage modulus (G?) and loss modulus (G??) increased with an increase in frequency. Rheological properties of both types of gel solutions were strongly influenced by the amount of concentration. The shear stress profiles demonstrated shear thinning in both types of gels. Viscosity of 1% agarose and 2% agarose was found comparable with 10% GelMA and 15% GelMA, respectively. Conclusions: Results obtained from experiments revealed that rotational rheometry can be confidently used to determine viscous and elastic response of hydrogels in the aqueous state. The results will help to select the right type of gel and amount of concentration for the bio-printing of tissues.
Languageen
PublisherBaqiyatallah University of Medical Sciences
SubjectAgarose
Biological Gels
Gelatin Methacryloyl
Rheology
Viscosity
TitleRheological characterization of biological hydrogels in aqueous state
TypeArticle
Issue Number3
Volume Number7
dc.accessType Abstract Only


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