Porcine cholecyst derived extracellular matrix (p-CEM) for reconstruction of full thickness skin wounds in rats
Author | Shakya, P. |
Author | Sharma, A.K. |
Author | Kumar, N. |
Author | Remya, V. |
Author | Mathew, D.D. |
Author | Dubey, P. |
Author | Singh, K. |
Author | Shrivastava, S. |
Author | Maiti, S.K. |
Author | Hasan, Anwarul |
Author | Singh K.P. |
Available date | 2022-05-21T10:18:34Z |
Publication Date | 2015 |
Publication Name | Wound Medicine |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1016/j.wndm.2015.11.001 |
Abstract | An acellular cholecyst derived extracellular matrix (p-CEM) of porcine origin was prepared using anionic biological detergent. Healing potential of (p-CEM) was compared with commercially available collagen sheet (b-CS) and open wound (C) in full-thickness skin wounds in rats. Thirty six clinically healthy adult Sprague Dawley rats of either sex were randomly divided into three equal groups. Under general anesthesia, a full-thickness skin wound (20?20mm2) was produced on the dorsum of each rat. The defect in group I was kept as open wound and was taken as control. In group II, the defect was repaired with commercially available collagen sheet (b-CS). In group III, the defect was repaired with cholecyst derived extracellular matrix of bovine origin (p-CEM). Healing was evaluated on the basis of wound contraction, gross, hematological, immunological and histopathological observations. On critical analysis of the observed parameters it was found that p-CEM has healing potential and shown better healing response than commercially available collagen sheet to reconstruct full thickness skin wounds in rats. |
Language | en |
Publisher | Elsevier GmbH |
Subject | Bovinecollagen sheet (b-CS) Porcine cholecyst derived extracellular matrix (p-CEM) Rats Wound healing |
Type | Article |
Volume Number | 11-Oct |
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Mechanical & Industrial Engineering [1343 items ]