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AuthorBuck E.
AuthorLee S.
AuthorGao Q.
AuthorTran S.D.
AuthorTamimi F.
AuthorStone L.S.
AuthorCerruti M.
Available date2022-05-31T19:01:18Z
Publication Date2022
Publication NameACS Biomaterials Science and Engineering
ResourceScopus
Identifierhttp://dx.doi.org/10.1021/acsbiomaterials.1c01434
URIhttp://hdl.handle.net/10576/31804
AbstractPoly(etheretherketone) (PEEK) implants suffer from poor osseointegration because of chronic inflammation. In this study, we hypothesized that adding NH2and COOH groups to the surface of PEEK could modulate macrophage responses by altering protein adsorption and improve its osseointegration. NH2and COOH-functionalized PEEK surfaces induced pro- and anti-inflammatory macrophage responses, respectively, and differences in protein adsorption patterns on these surfaces were related to the varied inflammatory responses. The macrophage responses to NH2surfaces significantly reduced the osteogenic differentiation of mesenchymal stem cells (MSCs). MSCs cultured on NH2surfaces differentiated less than those on COOH surfaces even though NH2surfaces promoted the most mineralization in simulated body fluid solutions. After 14 days in rat tibia unicortical defects, the bone around NH2surfaces had thinner trabeculae and higher specific bone surface than the bone around unmodified implants; surprisingly, the NH2implants significantly increased bone-binding over the unmodified implants, while COOH implants only showed a trend for increasing bone-binding. Taken together, these results suggest that both mineral-binding and immune responses play a role in osseointegration, and PEEK implant integration may be improved with mixtures of these two functional groups to harness the ability to reduce inflammation and bind bone strongly.
Languageen
PublisherAmerican Chemical Society
SubjectBody fluids
Bone
Cell culture
Flowcharting
Macrophages
Molecular biology
Pathology
Proteins
Stem cells
Surface chemistry
Anti-inflammatories
Bone-binding
Chronic inflammation
COOH group
Diazonia
Functionalized
Immune response
Mesenchymal stem cell
Osseointegration
Protein adsorption
Immune system
benzophenone derivative
ketone
macrogol
polyetheretherketone
polymer
animal
bone development
inflammation
osseointegration
rat
surface property
Animals
Benzophenones
Inflammation
Ketones
Osseointegration
Osteogenesis
Polyethylene Glycols
Polymers
Rats
Surface Properties
TitleThe Role of Surface Chemistry in the Osseointegration of PEEK Implants
TypeArticle
Pagination1506-1521
Issue Number4
Volume Number8
dc.accessType Abstract Only


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