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AuthorAlshahrani N.S.
AuthorAbu-Nada L.
AuthorRamirez Garcia-Luna J.L.
AuthorAl-Hamed F.S.
AuthorAlamri A.
AuthorMakhoul N.M.
AuthorTamimi F.
Available date2022-05-31T19:01:21Z
Publication Date2020
Publication NameJournal of Oral and Maxillofacial Surgery
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.joms.2020.06.027
URIhttp://hdl.handle.net/10576/31828
AbstractPurpose: Ranitidine has been found to have an impact on bone metabolism by suppressing osteoclastogenesis. We hypothesized that the use of ranitidine would impair bone healing and implant osseointegration. This study investigated the effect of postoperative administration of ranitidine on bone healing and osseointegration in rats. Materials and Methods: Twenty-two Sprague-Dawley rats underwent surgery to create a unicortical bone defect in each tibia. A titanium implant was placed on the right tibial defect, whereas the contralateral defect was left unfilled. After surgery, the rats were randomly divided into 2 groups receiving a daily dose of ranitidine or saline solution for 14 days and then euthanized for assessment of bone healing and osseointegration using micro?computed tomography (CT) and histomorphometry. Results: Micro-CT analysis of the bone defect showed a larger bone defect volume in the ranitidine group (0.82 � 0.13 ?L vs 0.66 � 0.16 ?L, P = .034), thinner cortical thickness (0.54 � 0.07 mm vs 0.63 � 0.11 mm, P = .026), and less bone regeneration at the defect site (40% � 12% vs 57% � 11%, P = .003). Implant-site micro-CT analysis showed less osseointegration in the ranitidine group (34.1% � 2.7% vs 43.5% � 2.1%, P = .014), and implant-site histologic analysis showed less medullary (P = .021), cortical (P = .001), and total (P = .003) bone-implant contact and less peri-implant bone volume?tissue volume (P = .002) in the ranitidine group. Histologic analysis for osteoclastic activity showed a lower number of osteoclasts in the ranitidine group (4.8 � 2.4 mm?2 vs 9.1 � 2.1 mm?2, P = .026). Conclusions: The postoperative use of ranitidine impaired bone healing and osseointegration. ? 2020 American Association of Oral and Maxillofacial Surgeons
Languageen
PublisherW.B. Saunders
Subjectranitidine
ranitidine
titanium
animal experiment
animal model
Article
controlled study
drug effect
female
fracture healing
fracture nonunion
in vivo study
micro-computed tomography
morphometry
nonhuman
osseointegration
osteoclast activity
postoperative period
rat
tibia fracture
animal
diagnostic imaging
Sprague Dawley rat
surgery
tibia
tooth implant
Animals
Dental Implants
Osseointegration
Ranitidine
Rats
Rats, Sprague-Dawley
Tibia
Titanium
X-Ray Microtomography
TitleRanitidine Impairs Bone Healing and Implant Osseointegration in Rats' Tibiae
TypeArticle
Pagination1943-1952
Issue Number11
Volume Number78
dc.accessType Abstract Only


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