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AuthorAl-Hamed F.S.
AuthorMaria O.M.
AuthorPhan J.
AuthorSubaie A.A.
AuthorGao Q.
AuthorMansour A.
AuthorNada L.A.
AuthorBoukhatem I.
AuthorElkashty O.A.
AuthorTran S.D.
AuthorLordkipanidz� M.
AuthorBadran Z.
AuthorTamimi F.
Available date2022-05-31T19:01:22Z
Publication Date2020
Publication NameBiomolecules
ResourceScopus
Identifierhttp://dx.doi.org/10.3390/biom10091318
URIhttp://hdl.handle.net/10576/31832
AbstractDonepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer?s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.
Languageen
PublisherMDPI AG
Subjectcholinesterase inhibitor
donepezil
cholinesterase inhibitor
donepezil
titanium
animal experiment
animal model
animal tissue
Article
bleeding time
blood clotting parameters
bone defect
bone mass
bone microarchitecture
bone mineralization
bone regeneration
bone volume
bone volume fraction
cell infiltration
female
fracture healing
histology
image analysis
micro-computed tomography
nonhuman
osseointegration
rat
soft tissue
thrombocyte function
animal
bone implant interface
bone prosthesis
chemistry
diagnostic imaging
drug effect
injury
osseointegration
pathology
Sprague Dawley rat
tibia
tibia fracture
wound healing
Animals
Bone Substitutes
Bone-Implant Interface
Cholinesterase Inhibitors
Donepezil
Female
Osseointegration
Rats
Rats, Sprague-Dawley
Tibia
Tibial Fractures
Titanium
Wound Healing
X-Ray Microtomography
TitlePostoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
TypeArticle
Pagination1-16
Issue Number9
Volume Number10
dc.accessType Abstract Only


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