عرض بسيط للتسجيلة

المؤلفGanji, Vijay
المؤلفSukik, Layan
المؤلفHoque, Bushra
المؤلفBoutefnouchet, Linda
المؤلفShi, Zumin
تاريخ الإتاحة2022-06-12T07:04:23Z
تاريخ النشر2022-06-09
اسم المنشورJournal of Personalized Medicine
المعرّفhttp://dx.doi.org/10.3390/jpm12060944
الاقتباسGanji, V.; Sukik, L.; Hoque, B.; Boutefnouchet, L.; Shi, Z. Association of Serum 25-Hydroxyvitamin D Concentration with Breast Cancer Risk in Postmenopausal Women in the US. J. Pers. Med. 2022, 12, 944. https://doi.org/10.3390/jpm12060944
معرّف المصادر الموحدhttp://hdl.handle.net/10576/32068
الملخصThe association between serum 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer risk in postmenopausal women is not well understood. The aim of this study was to investigate the association between serum 25(OH)D concentration and breast cancer in postmenopausal women in the United States using nationally representative sample surveys. We used the data from seven cycles of National Health and Nutrition Examination Surveys from 2001 to 2014. Participants were non-institutionalized postmenopausal women (n = 8108). In restricted cubic spline analysis, a significant, nonlinear, invert ‘U’ relationship was observed between serum 25(OH)D concentrations and breast cancer in postmenopausal women (p = 0.029). Overall, breast cancer risk was highest (OR = 1.5) between 70 nmol/L and 80 nmol/L of serum 25(OH)D concentration. Then after serum 25(OH)D 80 nmol/L concentration, the breast cancer risk declined. In multivariate-adjusted logistic regression, the risk of having breast cancer was significantly higher in serum 25(OH)D 75–<100 nmol/L category compared to the 25(OH)D < 30 nmol/L category [OR and 95% CI: 2.4 (1.4–4.0)]. In conclusion, serum vitamin D concentrations ≥ 100 nmol/L are associated with reduced risk of breast cancer in postmenopausal women. Controlled trials are required to verify if serum 25(OH)D ≥ 100 nmol/L offers protection against breast cancer in postmenopausal women.
راعي المشروعQatar University, QU Health
اللغةen
الناشرMDPI
الموضوعbreast cancer
cancer
NHANES
National Health and Nutrition Examination Survey
postmenopausal women
serum 25(OH)D
United States
vitamin D
العنوانAssociation of Serum 25-Hydroxyvitamin D Concentration with Breast Cancer Risk in Postmenopausal Women in the US
النوعArticle
رقم العدد6
رقم المجلد12
ESSN2075-4426
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة