SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations
| Author | Zupin, Luisa |
| Author | Moltrasio, Chiara |
| Author | Genovese, Giovanni |
| Author | Milani, Margherita |
| Author | Fontana, Francesco |
| Author | Ruscio, Maurizio |
| Author | Valerio Marzano, Angelo |
| Author | Crovella, Sergio |
| Available date | 2022-06-20T04:37:35Z |
| Publication Date | 2022-01-01 |
| Publication Name | European Journal of Dermatology |
| Identifier | http://dx.doi.org/10.1684/ejd.2022.4206 |
| Citation | Luisa Zupin, Chiara Moltrasio, Giovanni Genovese, Margherita Milani, Francesco Fontana, Maurizio Ruscio, Angelo Valerio Marzano, Sergio Crovella. SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations. European Journal of Dermatology. 2022;32(1):143-145. doi:10.1684/ejd.2022.4206 |
| ISSN | 11671122 |
| Abstract | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated [2]. Angiotensin-converting enzyme 2 (ACE2) is highly expressed in keratinocytes, suggesting percutaneous transmission as a potential route for SARS-CoV-2 infection [3]. Currently, the susceptibility of keratinocytes to SARS-CoV-2 has not been investigated. Thus, two HaCaT spontaneously . |
| Language | en |
| Publisher | John Libbey Eurotext |
| Subject | SARS-CoV-2 COVID-19 |
| Type | Article |
| Pagination | 143-145 |
| Issue Number | 1 |
| Volume Number | 32 |
| ESSN | 1952-4013 |
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Biological & Environmental Sciences [920 items ]
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COVID-19 Research [838 items ]