Diabetic foot ulcers (DFUs) that are not effectively treated could lead to partial or complete lower limb amputations. The lack of connective tissue growth factor (CTGF) and insulin-like growth factor (IGF-I) in DFUs results ...

Background: Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem ...

Superior corrosion resistance along with higher mechanical performance is becoming a primary requirement to decrease operational costs in the industries. Nickel-based phosphorus coatings have been reported to show better ...

Spatial mapping of heterogeneity in gene expression in cancer tissues can improve our understanding of cancers and help in the rapid detection of cancers with high accuracy and reliability. Significant advancements have ...

The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, ...

Achieving the healing of chronic diabetic ulcers, burn wounds and large traumatic wounds is a major clinical challenge. A variety of approaches have been undertaken to generate skin substitutes, wound healing patches or ...

The interaction of nanoparticles with biological systems can provide useful information about their therapeutic applications. The aluminum nanoparticles (Al2O3 NPs) were synthesized by laser ablation technique and ...

Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one ...

The importance of bone scaffolds has increased many folds in the last few years; however, during bone implantation, bacterial infections compromise the implantation and tissue regeneration. This work is focused on this ...

Impaired diabetic wounds are one of the major pathophysiological complications caused by persistent microbial infections, prolonged inflammation, and insufficient angiogenic responses. Here, we report the development of ...