تصفح Biological & Environmental Sciences حسب المؤلف "Marzano, Angelo Valerio"
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Autoinflammation in Syndromic Hidradenitis Suppurativa: The Role of AIM2.
Moltrasio, Chiara; Cagliani, Rachele; Sironi, Manuela; Clerici, Mario; Pontremoli, Chiara; Maronese, Carlo Alberto; Tricarico, Paola Maura; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( MDPI , 2023 , Report)AIM2 is a key cytoplasmatic pathogen-sensor that detects foreign DNA from viruses and bacteria; it can also recognize damaged or anomalous presence of DNA, promoting inflammasome assembly and activation with the secretion ... -
Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.
Moura, Ronald Rodrigues; Brandão, Lucas; Moltrasio, Chiara; Agrelli, Almerinda; Tricarico, Paola Maura; Maronese, Carlo Alberto; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Nature Research , 2023 , Article)Pyoderma gangrenosum (PG) is a rare inflammatory skin disease classified within the spectrum of neutrophilic dermatoses. The pathophysiology of PG is yet incompletely understood but a prominent role of genetics facilitating ... -
Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the Disease.
Moltrasio, Chiara; Tricarico, Paola Maura; Romagnuolo, Maurizio; Marzano, Angelo Valerio; Crovella, Sergio ( MDPI , 2022 , Article)Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease of the pilosebaceous unit, clinically consisting of painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin areas. ... -
Paraviral cutaneous manifestations associated to SARS-CoV-2 Omicron variant
Zupin, Luisa; Moltrasio, Chiara; Tricarico, Paola Maura; Del Vecchio, Cecilia; Fontana, Francesco; Marzano, Angelo Valerio; Crovella, Sergio... more authors ... less authors ( Taylor and Francis Group , 2022 , Article)Background: The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection ... -
Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
de Oliveira, Ana Sofia Lima Estevao; Bloise, Giovanna; Moltrasio, Chiara; Coelho, Antonio; Agrelli, Almerinda; Moura, Ronald; Tricarico, Paola Maura; Jamain, Stéphane; Marzano, Angelo Valerio; Crovella, Sergio; Cavalcanti Brandão, Lucas André... more authors ... less authors ( MDPI , 2022 , Article)Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, ... -
Variant Enrichment Analysis to Explore Pathways Functionality in Complex Autoinflammatory Skin Disorders through Whole Exome Sequencing Analysis.
Brandão, Lucas André Cavalcanti; Moura, Ronald Rodrigues de; Marzano, Angelo Valerio; Moltrasio, Chiara; Tricarico, Paola Maura; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy ...