Biological & Environmental Sciences: Recent submissions
Now showing items 181-200 of 920
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Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application
( Dove Press Ltd , 2023 , Article)Background: Hypertension is a leading cause of mortality and morbidity globally. Pharmacists can play a substantial role in decreasing the burden of the disease. Purpose: The primary aim of this study was to develop and ... -
Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months
( Elsevier , 2023 , Article)BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ... -
Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination
( American Medical Association , 2023 , Article)Importance: In the ongoing COVID-19 pandemic, there remain unanswered questions regarding the nature and importance of the humoral immune response against other coronaviruses. Although coinfection of the Middle East ... -
Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
( Elsevier , 2013 , Article)Background In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions. Methods Cell viability ... -
Determination of vascular reactivity of middle cerebral arteries from stroke and spinal cord injury animal models using pressure myography
( Humana Press Inc. , 2016 , Book chapter)Stroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. ... -
Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2
( American Physiological Society , 2013 , Article)The second messenger cyclic AMP (cAMP) plays a vital role in vascular physiology, including vasodilation of large blood vessels. We recently demonstrated cAMP activation of Epac-Rap1A and RhoA-Rho-associated kinase ... -
Cyclic AMP-Rap1A signaling activates RhoA to induce α2c-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells
( American Physiological Society , 2012 , Article)Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, ... -
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
( Elsevier , 2016 , Article)Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ... -
CAMP induces adhesion of microvascular smooth muscle cells to fibronectin via an epac-mediated but PKA-independent mechanism
( Cell Physiol Biochem Press , 2012 , Article)Background/Aims: Vascular smooth muscle cells (VSMCs) play important roles, both in physiologic and pathophysiologic processes. Adhesion of these cells is critical for their proper functioning, especially in resistance-sized ... -
Thymus vulgaris (Thyme) inhibits proliferation, adhesion, migration, and invasion of human colorectal cancer cells
( Mary Ann Liebert Inc. , 2015 , Article)Colorectal cancer (CRC) remains one of the most common malignancies and a leading cause of cancer-related deaths. Its prognosis remains poor for patients with several grades of this disease. This underscores the need for ... -
Molecular Insights Into SARS COV-2 Interaction With Cardiovascular Disease: Role of RAAS and MAPK Signaling
( Frontiers Media S.A. , 2020 , Article)In December 2019, reports of viral pneumonia came out of Wuhan city in Hubei province in China. In early 2020, the causative agent was identified as a novel coronavirus (CoV) sharing some sequence similarity with SARS-CoV ... -
Rhus coriaria L. (Sumac) evokes endothelium-dependent vasorelaxation of rat aorta: Involvement of the cAMP and cGMP pathways
( Frontiers Media S.A. , 2018 , Article)Rhus coriaria L. (sumac) is widely used in traditional remedies and cuisine of countries of the Mediterranean as well as Central and South-West Asia. Administration of sumac to experimental models and patients with diverse ... -
Assessment of water bodies of united arab emirates coastal sabkhas as potential sites for natural salinity gradient solar ponds
( ASCE - American Society of Civil Engineers , 2008 , Article)Increasing population and growing demands from both agriculture and industry in the United Arab Emirates (UAE) necessitate the need to provide inexpensive fresh water. The only feasible source of such water is desalination. ... -
The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis
( Wiley Blackwell , 2019 , Article Review)Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
Effect of temperature and sunlight on the leachability potential of BPA and phthalates from plastic litter under marine conditions
( Elsevier , 2023 , Article)This study investigates the leaching potential of several additives embedded in six different plastic types when exposed to extreme simulated marine conditions for 140 days. The findings achieved herein contribute to a ... -
Bio-Based Self-Healing Concrete for Sustainable and Durable Concrete Infrastructure
( Qatar University Press , 2023 , Conference)In this study, bio-self-healing concrete was manufactured using a natural phenomenon called microbial-induced calcium carbonate precipitation (MICP). The bacillus cereus bacteria isolated from Qatari soil was used for this ... -
Nanomedicine tactics in cancer treatment: Challenge and hope
( Elsevier Ireland Ltd , 2022 , Article)Defeating cancer is the ultimate challenge and goal of oncologists, facing various obstacles along with finding effective anti-cancer therapies and understanding drug delivery mechanisms. Additionally, the translation of ... -
Growth performance, intestinal histomorphology, gut microflora and ghrelin gene expression analysis of broiler by supplementing natural growth promoters: A nutrigenomics approach
( Elsevier B.V. , 2021 , Article)In an epoch of escalating number of antibiotic-resistance bacteria, there is a dire need to develop efficient and novel feeding strategies for animal nutrition as alternatives to antibiotics. Here, implicating nutrigenomic ... -
Combating immunotoxicity of aflatoxin B1 by dietary carbon supplementation in broiler chickens
( Springer Science and Business Media Deutschland GmbH , 2021 , Article)Aflatoxin B1 (AFB1) is a secondary metabolite of some Aspergillus species that contaminate the agricultural commodities intended for animal and human consumption. The present in vivo study aimed to evaluate activated ...
