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AuthorSun, Xiaomin
AuthorLi, Zhongying
AuthorChen, Yingxin
AuthorXu, Tao
AuthorShu, Jing
AuthorShi, Lin
AuthorShi, Zumin
Available date2022-11-16T06:03:36Z
Publication Date2022-10-29
Publication NameNutrients
Identifierhttp://dx.doi.org/10.3390/nu14214561
CitationSun, X.; Li, Z.; Chen, Y.; Xu, T.; Shu, J.; Shi, L.; Shi, Z. Interactive Effects of Methionine and Lead Intake on Cognitive Function among Chinese Adults. Nutrients 2022, 14, 4561. https://doi.org/10.3390/nu14214561
URIhttp://hdl.handle.net/10576/36471
AbstractThe association between methionine intake and cognitive function is inconclusive. We aimed to assess the association between methionine intake and cognitive function in Chinese adults and to explore the interaction between methionine and lead intake. Data from 4852 adults aged ≥55 years from the China Health and Nutrition Survey were used. Cognitive function was measured in 1997, 2000, 2004, and 2006. A 3-day, 24-hour recall was used to assess methionine and lead intake from different protein sources. Multivariable mixed linear regression was used in the analyses. Total methionine intake was positively correlated with cognition. There was a significant interaction between animal methionine and lead intakes. In subgroup analyses, across the quartiles of animal methionine intake, the regression coefficients (95% CI) for global cognition were 0.00, 0.57 (0.17 to 0.98), 1.18 (0.73 to 1.62), and 1.80 (1.31 to 2.29), respectively, while they were 0.00, -0.73 (-1.12 to -0.34), -0.83 (-1.26 to -0.41), and -1.72 (-2.22 to -1.22) across the quartiles of plant methionine intake, respectivelyThe association between animal methionine intake and cognition was stronger among adults with a low lead intake. In conclusion, animal methionine and plant methionine intake were positively and inversely associated with cognition, respectively. Lead intake modified the association between animal methionine intake and cognition.
SponsorThis study was supported in part by research grants from the Natural Scientific Foundation in Qinghai Province (2019-ZJ-932Q), and the National Key Research and Development Program of China (grant numbers: 2017YFC0907200 and 2017YFC0907201).
Languageen
PublisherMDPI
Subjectanimal methionine
cognitive function
interactive effect
lead intake
plant methionine
TitleInteractive Effects of Methionine and Lead Intake on Cognitive Function among Chinese Adults.
TypeArticle
Issue Number21
Volume Number14
ESSN2072-6643
dc.accessType Open Access


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