Synthesis and biological activity of some new 3-and 6-substituted coumarin amino acid derivatives. Part I
Author | El-Naggar, A. M. |
Author | Ahmed, F. S. M. |
Author | El-Salam, A. M. A. |
Author | Radi, M. A. |
Author | Latif, M. S. A. |
Available date | 2015-11-05T11:29:51Z |
Publication Date | 1981 |
Publication Name | journal of heterocyclic chemistry |
Resource | Wiley Online library |
Citation | El-Naggar, A. M., Ahmed, F. S. M., El-Salam, A. M. A., Radi, M. A. and Latif, M. S. A. (1981), Synthesis and biological activity of some new 3-and 6-substituted coumarin amino acid derivatives. Part I. J. Heterocyclic Chem., 18: 1203–1207. |
ISSN | 1943-5193 |
Abstract | The synthesis of 6-nitrocouarrain-3-CO-amino acids and their corresponding methyl esters (II-XVII) and some dipeptide methyl esters (XVIII-XXVI) are described. 6-(N-Tosyl- or N-phthalylaminoacyl)aminocoumarin-3-carboxylic acid methyl esters (XXXIV-XL) and 3-(N-phthalyl- or N-tosylaminoacytyaminocoumarins (XLV-LVI) have been prepared via the carbodiimide and acid chloride methods. Hydrazinolysis of 3- or 6-(N-phthalylaminoacyl)aminocoumarin derivatives in tetraline gave the corresponding 3- and 6-(aminoacyl)aminocoumarins and the carboxylic acid hydrazides (XLI-LVIII), respectively. 3-(N-Tosyl-L-Val-L-Leu-)aminocoumarin (LIX) was synthesized via the azide method. Twenty four of various substituted 3- and 6-aminoacylcoumarin derivatives were found to possess specific antimicrobial activities towards different microorganisms. |
Language | en |
Publisher | Wiley-Blackwell |
Subject | Amino acids coumarin |
Type | Article |
Issue Number | 6 |
Volume Number | 18 |
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Chemistry & Earth Sciences [557 items ]