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المؤلفGuaraná, Werbson Lima
المؤلفLima, Camilla Albertina Dantas
المؤلفBarbosa, Alexandre Domingues
المؤلفCrovella, Sergio
المؤلفSandrin-Garcia, Paula
تاريخ الإتاحة2022-12-29T05:58:16Z
تاريخ النشر2022
اسم المنشورGenes
المعرّفhttp://dx.doi.org/10.3390/genes13122271
الاقتباسGuaraná, W.L.; Lima, C.A.D.; Barbosa, A.D.; Crovella, S.; Sandrin-Garcia, P. Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity? Genes 2022, 13, 2271. https://doi.org/10.3390/genes13122271
معرّف المصادر الموحدhttp://hdl.handle.net/10576/37771
الملخصThe immune system plays a critical role in bone homeostasis and, consequently, in the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces the inflammasome and increases production of pro-inflammatory cytokines, such as IL-1β and IL-18. NLRP3 inflammasome complex genes have been related with bone homeostasis in cellular and animal models. Here, we performed an association study evaluating SNVs (single-nucleotide variants) in inflammasome NLRP3 pathway genes (NLRP3, CARD8, CASP1, IL-18, and IL-1β) to assess whether variants in these genes could be related to susceptibility to primary OP in postmenopausal women. We genotyped 196 postmenopausal OP patients and 103 healthy controls using SNV-specific Taqman probes. Data and statistical analyses were performed using the SNPstats and GraphPad Prism 8 software. We showed an association between NLRP3 rs35829419 CA genotype and lower bone mineral density (BMD) mean at the lumbar spine ( = 0.001); we also observed an association between IL-1β rs16944 AA genotype and higher BMD mean at the total hip ( = 0.009). The IL-1β rs16944 GG was associated with lower alkaline phosphatase levels (ALP) ( = 0.009), and the IL-18 rs1946519 AA was associated with lower vitamin D levels ( = 0.018). Additionally, OP patients presented deficient vitamin D and parathyroid hormone (PTH). The NLRP3 inflammasome complex SNVs were associated with OP severity, possibly indicating these genes' participation in bone metabolism and its dysregulation.
راعي المشروعThis research was funded by the following Brazilian research agencies: CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico).
اللغةen
الناشرMDPI
الموضوعNLRP3
bone mineral density
inflammasome
osteoporosis
single-nucleotide variants
vitamin D
العنوانCan Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?
النوعArticle
رقم العدد12
رقم المجلد13
ESSN2073-4425
dc.accessType Open Access


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