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AuthorSukik, Ayah
AuthorAlalwani, Joud
AuthorGanji, Vijay
Available date2023-01-05T08:19:37Z
Publication Date2023-01-04
Publication NameIJMS
Identifierhttp://dx.doi.org/10.3390/ijms24020940
CitationSukik, A.; Alalwani, J.; Ganji, V. Vitamin D, Gut Microbiota, and Cardiometabolic Diseases-A Possible Three-Way Axis. Int. J. Mol. Sci. 2023, 24, 940. https://doi.org/10.3390/ijms24020940
URIhttp://hdl.handle.net/10576/37983
AbstractMetabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases such as obesity, type-2 diabetes mellitus (T2DM), and cardiovascular diseases. Emerging evidence suggests that vitamin D deficiency links to cardiometabolic diseases through microbiota. A combination of poor vitamin D status and dysbiosis may contribute to the progression of cardiometabolic diseases. Therefore, in this review, we present the relationship among vitamin D, microbiota, and cardiometabolic diseases with a focus on MetSyn. We searched major databases for reports on vitamin D, microbiota, and MetSyn until June 2022. We reviewed 13 reports on the relation between vitamin D and MetSyn (6 randomized controlled and 7 cross-sectional studies) and 6 reports on the effect of vitamin D on the gut microbiome. Adequate vitamin D status has a beneficial effect on gut microbiota, therefore preventing the progression of MetSyn. Further, well-controlled studies are needed for a better understanding of the mechanisms of action involving vitamin D and microbiota in the pathogenesis of cardiometabolic diseases.
SponsorHuman Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar
Languageen
PublisherMDPI
Subject25-hydroxyvitamin D
diabetes
gut microbiome
metabolic syndrome
microbiota
obesity
type-2 diabetes
vitamin D
TitleVitamin D, Gut Microbiota, and Cardiometabolic Diseases: A Possible Three-Way Axis
TypeArticle
Issue Number2
Volume Number24
ESSN1422-0067
dc.accessType Open Access


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