Browsing QU Health Research by Title
Now showing items 38-57 of 62
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Nano-targeting vascular remodeling in cancer: Recent developments and future directions
( Elsevier , 2022 , Article Review)Tumor growth and progression are strictly dependent on the adequate blood supply of oxygen and nutrients. The formation of new blood vessels and vascular networks is essential to ensure this demand. Blood vessels also ... -
Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
( Elsevier , 2022 , Article)Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including ... -
Novel SPEA Superantigen Peptide Agonists and Peptide Agonist-TGFαL3 Conjugate. In Vitro Study of Their Growth-Inhibitory Effects for Targeted Cancer Immunotherapy
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Bacterial superantigens (SAgs) are effective T-cell stimulatory molecules that lead to massive cytokine production. Superantigens crosslink between MHC class II molecules on the Antigen Presenting Cells (APC) and TCR on ... -
Outcomes of critically ill COVID-19 patients boarding in the emergency department of a tertiary care center in a developing country: a retrospective cohort study
( Springer Nature , 2023 , Article)Background: Boarding of critically ill patients in the emergency department (ED) has long been known to compromise patient care and affect outcomes. During the COVID-19 pandemic, multiple hospitals worldwide experienced ... -
Ovarian torsion: A retrospective case series at a tertiary care center emergency department
( Public Library of Science , 2024 , Article)Ovarian torsion (OT) is a gynecological emergency that can have diverse clinical presentations makings its diagnosis especially challenging. Few studies exist in the literature describing the clinical presentation as well ... -
Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
( Elsevier , 2021 , Article)Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients’ quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines ... -
Potassium Ion Channels in Glioma: From Basic Knowledge into Therapeutic Applications
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Ion channels, specifically those controlling the flux of potassium across cell membranes, have recently been shown to exhibit an important role in the pathophysiology of glioma, the most common primary central nervous ... -
Predictors for hospital admission in emergency department patients with benign paroxysmal positional vertigo: A retrospective review.
( Public Library of Science , 2023 , Article)This study aims to assess the incidence of Emergency Department (ED) visits for benign paroxysmal positional vertigo (BPPV), describe patient characteristics, management practices and predictors of inpatient admission of ... -
Prospective cohort study of vitamin D deficiency in pregnancy: Prevalence and limited effectiveness of 1000 IU vitamin D supplementation
( SAGE , 2024 , Article)Background: Vitamin D deficiency is highly prevalent worldwide among pregnant women. Although vitamin D supplementation is effective in improving vitamin D status, the safety and optimal dosing of vitamin D supplementation ... -
Protein glycation – biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine
( Elsevier , 2021 , Article)Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA1c (A1C). It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
Psychometric Properties and Assessment of Knowledge, Attitude, and Practice Towards ChatGPT in Pharmacy Practice and Education: a Study Protocol
( Springer Science and Business Media Deutschland GmbH , 2023 , Article)ChatGPT represents an advanced conversational artificial intelligence (AI), providing a powerful tool for generating human-like responses that could change pharmacy prospects. This protocol aims to describe the development, ... -
Questionable research practices of medical and dental faculty in Pakistan – a confession
( Springer Nature , 2024 , Article)Purpose: Intellectual honesty and integrity are the cornerstones of conducting any form of research. Over the last few years, scholars have shown great concerns over questionable research practices (QRPs) in academia. This ... -
A review of technical and quality assessment considerations of audio-visual and web-conferencing focus groups in qualitative health research
(2023 , Article)The transition from the conventional approach to an online setting in conducting focus groups (FGs) for qualitative research is an increasingly adopted approach in health-related research. The purpose of this narrative ... -
Revolutionizing cancer care strategies: immunotherapy, gene therapy, and molecular targeted therapy
( Springer Science and Business Media B.V. , 2024 , Other)Despite the availability of technological advances in traditional anti-cancer therapies, there is a need for more precise and targeted cancer treatment strategies. The wide-ranging shortfalls of conventional anticancer ... -
Statistical methods and resources for biomarker discovery using metabolomics.
( BMC , 2023 , Article Review)Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ... -
Surface plasmon resonance-based synthesis of gold nanorods for sensing applications
( Springer , 2023 , Article)Gold nanomaterials possess leading interest in the field of nanomaterials due to their vast applications both in advanced chemical and medicinal industries. Gold nanorods (AuNRs) were synthesized via a seed-mediated growth ... -
Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model
( MDPI , 2023 , Article)Cancer is the second leading cause of death worldwide, and triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha ... -
The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes
( IMR Press Limited , 2022 , Article)Background: Humanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression ... -
Trehalose-conjugated lentil-casein protein complexes prepared by structural interaction: Effects on water solubility and protein digestibility
( Elsevier , 2024 , Article)The two limiting factors for lentil protein utilization are water solubility and digestibility. In this study, we utilized two non-thermal techniques: (1) protein complexation of lentil and casein proteins using the ...