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المؤلفJie, Yang
المؤلفXia, Yujia
المؤلفSun, Yanan
المؤلفGuo, Yufei
المؤلفShi, Zumin
المؤلفCristina do Vale Moreira, Nayla
المؤلفZuo, Hui
المؤلفHussain, Akhtar
تاريخ الإتاحة2023-05-14T05:23:17Z
تاريخ النشر2023-05-31
اسم المنشورDiabetes Research and Clinical Practice
المعرّفhttp://dx.doi.org/10.1016/j.diabres.2023.110662
الاقتباسYang, J., Xia, Y., Sun, Y., Guo, Y., Shi, Z., do Vale Moreira, N. C., ... & Hussain, A. (2023). Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials. Diabetes Research and Clinical Practice, 110662.‏
الرقم المعياري الدولي للكتاب01688227
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0168822723004229
معرّف المصادر الموحدhttp://hdl.handle.net/10576/42660
الملخصAimsWeight reduction is fundamental for the management and remission of diabetes. We aimed to assess ethnic differences in the effects of lifestyle weight-loss interventions on HbA1c levels in overweight or obese adults with type 2 diabetes mellitus (T2DM). MethodsWe systematically searched PubMed/MEDLINE and Web of Science online databases up to 31 Dec 2022. Randomized controlled trials using lifestyle weight-loss interventions in overweight or obese adults with T2DM were selected. We performed subgroup analyses to explore the heterogeneity across different ethnicities (Asians, White/Caucasians, Black/Africans and Hispanics). A random effects model was applied to calculate weighted mean difference (WMD) with 95% confidence interval (CI). ResultsThirty studies including 7580 subjects from different ethnicities were identified according to the predefined inclusion and exclusion criteria. HbA1c levels were significantly reduced by lifestyle weight-loss intervention. Notably, a significantly beneficial effect on HbA1c was observed in White/Caucasians (WMD = -0.59, 95% CI: −0.90, −0.28, P < 0.001) and Asians (WMD = -0.48, 95% CI: −0.63, −0.33, P < 0.001), but not in the Black/African or Hispanic group (both P > 0.05). The findings remained essentially unchanged in the sensitivity analysis. ConclusionsLifestyle weight-loss interventions had distinct beneficial effects on HbA1c levels in different ethnic groups with T2DM, especially in Caucasians and Asians.
اللغةen
الناشرElsevier
الموضوعDiabetes
Lifestyle intervention
HbA1c
Ethnicity
Weight loss
Randomized controlled trial
العنوانEffect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials
النوعArticle
رقم المجلد199
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.accessType Open Access


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