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AuthorJie, Yang
AuthorXia, Yujia
AuthorSun, Yanan
AuthorGuo, Yufei
AuthorShi, Zumin
AuthorCristina do Vale Moreira, Nayla
AuthorZuo, Hui
AuthorHussain, Akhtar
Available date2023-05-14T05:23:17Z
Publication Date2023-05-31
Publication NameDiabetes Research and Clinical Practice
Identifierhttp://dx.doi.org/10.1016/j.diabres.2023.110662
CitationYang, J., Xia, Y., Sun, Y., Guo, Y., Shi, Z., do Vale Moreira, N. C., ... & Hussain, A. (2023). Effect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials. Diabetes Research and Clinical Practice, 110662.‏
ISSN01688227
URIhttps://www.sciencedirect.com/science/article/pii/S0168822723004229
URIhttp://hdl.handle.net/10576/42660
AbstractAimsWeight reduction is fundamental for the management and remission of diabetes. We aimed to assess ethnic differences in the effects of lifestyle weight-loss interventions on HbA1c levels in overweight or obese adults with type 2 diabetes mellitus (T2DM). MethodsWe systematically searched PubMed/MEDLINE and Web of Science online databases up to 31 Dec 2022. Randomized controlled trials using lifestyle weight-loss interventions in overweight or obese adults with T2DM were selected. We performed subgroup analyses to explore the heterogeneity across different ethnicities (Asians, White/Caucasians, Black/Africans and Hispanics). A random effects model was applied to calculate weighted mean difference (WMD) with 95% confidence interval (CI). ResultsThirty studies including 7580 subjects from different ethnicities were identified according to the predefined inclusion and exclusion criteria. HbA1c levels were significantly reduced by lifestyle weight-loss intervention. Notably, a significantly beneficial effect on HbA1c was observed in White/Caucasians (WMD = -0.59, 95% CI: −0.90, −0.28, P < 0.001) and Asians (WMD = -0.48, 95% CI: −0.63, −0.33, P < 0.001), but not in the Black/African or Hispanic group (both P > 0.05). The findings remained essentially unchanged in the sensitivity analysis. ConclusionsLifestyle weight-loss interventions had distinct beneficial effects on HbA1c levels in different ethnic groups with T2DM, especially in Caucasians and Asians.
Languageen
PublisherElsevier
SubjectDiabetes
Lifestyle intervention
HbA1c
Ethnicity
Weight loss
Randomized controlled trial
TitleEffect of lifestyle intervention on HbA1c levels in overweight and obese adults with type 2 diabetes across ethnicities: A systematic review and meta-analysis of randomized controlled trials
TypeArticle
Volume Number199
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.accessType Open Access


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