College of Pharmacy: المرسلات الحديثة
السجلات المعروضة 1021 -- 1040 من 1280
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Preparation and characterization of letrozole-loaded poly(d,l-lactide) nanoparticles for drug delivery in breast cancer therapy
( Taylor and Francis Ltd , 2019 , Article)Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism, and a range of side effects. In this study, polymer-based ... -
Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects
( Taylor and Francis Ltd , 2019 , Article)Although a plethora of studies have examined tobacco smoke-cancer disease association, the involvement of cellular genetic toxicity remains unclear. Therefore, the present study provides molecular evidence for a pathway ... -
Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia
( Taylor and Francis Ltd , 2019 , Article)Sanguinarine (Sang), a plant-derived compound isolated from the roots of Sanguinaria canadensis was evaluated for its potential pro-apoptotic effects in precursor B acute lymphoblastic leukemia (Pre-ALL) cell lines. Treatment ... -
A systematic review of the outcome data supporting the Healthy Living Pharmacy concept and lessons from its implementation
( Public Library of Science , 2019 , Article)Background The Healthy Living Pharmacy (HLP) project, launched in England, UK in 2009 was a novel approach of introducing public health services within community pharmacy to tackle local health inequalities. A national ... -
Impact of a Collaborative Pharmaceutical Care Service Among Patients With Diabetes in an Ambulatory Care Setting in Qatar: A Multiple Time Series Study
( Elsevier Inc. , 2019 , Article)Background Diabetes mellitus is highly prevalent in the Middle East and the burden associated with it is dramatically increasing. Pharmacists working in collaborative healthcare teams have an important role to improve ... -
Precise fabrication of porous one-dimensional gC3N4 nanotubes doped with Pd and Cu atoms for efficient CO oxidation and CO2 reduction
( Elsevier B.V. , 2019 , Article)Rational design of graphitic carbon nitride nanostructures (gC3N4) is vital for various catalytic applications. Herein, we synthesized porous gC3N4 nanotubes (gC3N4NTs) doped with Pd and Cu (Pd/Cu/gC3N4NTs) via the consecutive ... -
Evaluations of Morphine and Fentanyl for Mechanically Ventilated Patients With Respiratory Disorders in Intensive Care: A Systematic Review of Methodological Trends and Reporting Quality
( Elsevier Inc. , 2019 , Article)Background: Mechanically ventilated patients with respiratory disorders may require sedatives, such as opioids. Objectives: To define methodological trends, gaps, and the reporting quality of the comparative clinical and ... -
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
( Elsevier , 2020 , Article)Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ... -
Patients' lived experiences with antineoplastic medicines for the management of malignant solid tumours: A systematic review.
( Elsevier , 2020 , Article)Antineoplastic medicines affect the patients' physical and psychosocial well-being posing challenges for patients, caregivers and healthcare professionals. However, little is known about the patients' lived experience with ... -
Human Factors approaches to evaluating outpatient parenteral antimicrobial therapy services: A systematic review.
( Elsevier , 2019 , Article)The expansion in terms of available treatment options and models of care has led to a growing global momentum for outpatient antimicrobial therapy (OPAT) services. A systematic review was undertaken to explore Human Factors ... -
Mixed-methods approach to determine adherence, knowledge and behavioral determinants associated with medication wastage.
( Elsevier , 2019 , Article)While literature quantifying medication wastage and assessing public's knowledge and practices about medication disposal is substantial, less attention is given to the public's knowledge and behavior pertaining to medication ... -
Practice implications of an antimicrobial stewardship intervention in a tertiary care teaching hospital, Qatar
( World Health Organization , 2019 , Article)Background: Antibiotic misuse is a worldwide public health problem and has been associated with increased morbidity, length of hospital stay, mortality, healthcare costs, and most importantly antibiotic resistance. Aims: ... -
Pass-fail decisions for borderline performers after a summative objective structured clinical examination
( American Association of Colleges of Pharmacy , 2019 , Article)Objective. To determine what expert assessors value when making pass-fail decisions regarding pharmacy students based on summative data from objective structured clinical examinations (OSCE), and to determine the reliability ... -
Approaches to Direct Oral Anticoagulant Selection in Practice
( SAGE Publications Ltd , 2019 , Article Review)Direct oral anticoagulants (DOACs) carry many advantages over warfarin and are now considered first line or an alternative for mnay thromboembolic disorders. With the emergence of 5 DOAC agents to the market as well as the ... -
Evaluation of community pharmacists' preparedness for the provision of cardiovascular disease risk assessment and management services: A study with simulated patients
( Elsevier Inc. , 2019 , Article)Background Individuals who suffer from major cardiovascular events every year have one or more risk factors. Cardiovascular disease (CVD) risk assessment is an important strategy for the early identification of modifiable ... -
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
( MDPI AG , 2019 , Article)Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ... -
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
( Springer-Verlag France , 2019 , Article)Background Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM ... -
Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment
( Springer Netherlands , 2019 , Article)Post-traumatic stress disorder (PTSD) is precipitated by exposure to severe traumatic events such as wars, natural disasters, catastrophes, or other traumatic events. Withania somnifera (WS) Dunal (family: Solanaceae) known ... -
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting
( Excerpta Medica Inc. , 2019 , Article)Purpose: Morphine and fentanyl opioids are common analgesic agents for consideration in the neonatal intensive care unit (NICU) for neonates with respiratory distress syndrome (RDS) and undergoing mechanical ventilation ... -
Perceptions and expectations of health care providers towards clinical pharmacy services in a mental health hospital in Qatar
( Elsevier B.V. , 2019 , Article)Background: With the growing burden of mental disorders, pharmacists are ideally positioned to play an important role in supporting people with a mental illness. However, the value of clinical pharmacists within mental ...