Browsing Biomedical Research Center Research by Title
Now showing items 642-661 of 724
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The tale of an endemic shrimp’s exceptional osmoregulation and the ancient Athalassic mangrove oasis
( Springer Nature , 2024 , Article)The hyperarid mangrove in the Middle East is characterised by the absence of rivers or freshwater inputs and is one of the most extreme settings of this ecosystem on Earth. Endemic to Qatar’s hyperarid mangroves, a Palaemon ... -
A TaqMan real-time PCR-based assay for the identification of Fasciola spp.
( Elsevier , 2011 , Article)Real time quantitative PCR (qPCR) is one of the key technologies of the post-genome era, with clear advantages compared to normal end-point PCR. In this paper, we report the first qPCR-based assay for the identification ... -
Targeting triple negative breast cancer heterogeneity with chalcones: a molecular insight.
( Informa Healthcare , 2019 , Article Review)Triple negative breast cancers (TNBCs) are aggressive heterogeneous cancers with not yet determined conventional targeted medication. Therefore, identification of new alternatives or improved treatment options to combat ... -
A Terpenoid-Rich Fraction of Inula viscosa: Its Chemical Composition, Antioxidant Capacity, and Anticancerous Effects Against Human Lung Cancer Cells
( Preprints , 2024 , Article)Inula viscosa is a widely used plant in traditional Mediterranean and Middle Eastern medicine for various illnesses. I. viscosa has been shown to have anticancerous effects against various cancers, but its effects against ... -
Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model
( MDPI , 2023 , Article)Cancer is the second leading cause of death worldwide, and triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha ... -
Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article)The aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development. We used the chicken embryo at 3 days of incubation as a model to evaluate the ... -
The Cellular Interplay Between CD44 and Na+/H+ Exchanger1 in Cardiac Remodeling
( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)Background: Extracellular matrix (ECM) remodeling is a characteristic feature of cardiac remodeling which, if left untreated, progresses to heart failure. Cardiac fibroblasts, the major cellular component of the myocardium, ... -
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
( Qatar University Press , 2021 , Poster)Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the ... -
The effect of aluminum oxide on red blood cell integrity and hemoglobin structure at nanoscale
( Elsevier B.V. , 2019 , Article)Herein, we explored the interaction of Al2O3 NPs with RBCs and Hb to determine the effect of Al2O3 NPs on hemolytic activity and Hb denaturation. The percentage of hemolysis of extracts and direct contact assays triggered ... -
The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes
( IMR Press Limited , 2022 , Article)Background: Humanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression ... -
The Effects of Class IV Hemorrhagic Hypotensive Shock and Its Resuscitation with Fluids and Adjuvant Vasopressors or Cellular Energy Replenishment on the Splanchnic Microcirculation
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Traumatic exsanguination leading to class IV hemorrhagic shock as defined by the Committee on Trauma of the American College of Surgeons requires aggressive resuscitation with crystalloids and packed cells together with ... -
The eutherian pseudoautosomal region
( S. Karger AG , 2016 , Article Review)The pseudoautosomal region (PAR) is a unique segment of sequence homology between differentiated sex chromosomes where recombination occurs during meiosis. Molecular and functional properties of the PAR are distinctive ... -
The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article Review)Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30-45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors ... -
The Implementation of an Integrated Management System at Qatar Biobank
( Mary Ann Liebert Inc. , 2019 , Article)Qatar Biobank (QBB) is a platform that will make vital health research possible through its collection of samples and information on health and lifestyle from the local population of Qatar. The goal of QBB is to collect, ... -
The landscape of genetic variations in non-syndromic primary ovarian insufficiency in the MENA region: a systematic review
( Frontiers Media SA , 2023 , Article Review)Introduction: Premature ovarian insufficiency (POI) is a primary cause of infertility with variable clinical manifestations. POI is a multifactorial disease with both environmental and known genetic etiologies, but data ... -
The power of phytochemicals combination in cancer chemoprevention
( Ivyspring International Publisher , 2020 , Article Review)Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ... -
The QChip1 knowledgebase and microarray for precision medicine in Qatar
( Nature Research , 2022 , Article)Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop "QChip1," an inexpensive ... -
The Spectrum of Antibiotic Prescribing during COVID-19 Pandemic: A Systematic Literature Review
( Mary Ann Liebert Inc. , 2021 , Article Review)Objectives: Over the last decades, there has been a significant increase in antimicrobial prescribing and consumption associated with the development of patients' adverse events and antimicrobial resistance (AMR) to the ... -
The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases
( Springer Science and Business Media Deutschland GmbH , 2022 , Article Review)Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several studies in the Arab world, but the frequency and spectrum of these translocations ... -
The stereological, immunohistological, and gene expression studies in an infected ischemic wound in diabetic rats treated by human adipose-derived stem cells and photobiomodulation
( Institute for Ionics , 2023 , Article)We investigated the impacts of photobiomodulation (PBM) and human allogeneic adipose-derived stem cells (ha-ADS) together and or alone applications on the stereological parameters, immunohistochemical characterizing of M1 ...
