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Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study

Shurrab, Farah M.; Al-Sadeq, Duaa W.; Abou-Saleh, Haissam; Al-Dewik, Nader; Elsharafi, Amira E.; ... more authors ... less authors ( MDPI , 2022 , Report)

The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was ...

Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar’s experience

Bsat, Raghid; Chemaitelly, Hiam; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; ... more authors ... less authors ( International Society of Global Health , 2022 , Article)

Background: The effective reproduction number, Rt, is a tool to track and understand epidemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset ...

Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants.

Altarawneh, Heba N; Chemaitelly, Hiam; Ayoub, Houssein H; Hasan, Mohammad R; Coyle, Peter; ... more authors ... less authors ( Massachusetts Medical Society , 2022 , Article)

The BA.4 and BA.5 subvariants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant have shown the capacity of escaping from neutralizing antibodies.1 These subvariants had an ...

Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage

Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ... less authors ( Nature Research , 2022 , Article)

There is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other ...

Protection from previous natural infection compared with mRNA vaccination against SARS-CoV-2 infection and severe COVID-19 in Qatar: a retrospective cohort study

Hiam, Chemaitelly; Ayoub, Houssein H; AlMukdad, Sawsan; Coyle, Peter; Tang, Patrick; ... more authors ... less authors ( Elsevier , 2022 , Article)

BackgroundUnderstanding protection conferred by natural SARS-CoV-2 infection versus COVID-19 vaccination is important for informing vaccine mandate decisions. We compared protection conferred by natural infection versus ...

Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

Al-Nesf, Maryam A. Y.; Abdesselem, Houari B.; Bensmail, Ilham; Ibrahim, Shahd; Saeed, Walaa A. H.; ... more authors ... less authors ( Nature Research , 2022 , Article)

COVID-19 complications still present a huge burden on healthcare systems and warrant predictive risk models to triage patients and inform early intervention. Here, we profile 893 plasma proteins from 50 severe and 50 ...

Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines

Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; ... more authors ... less authors ( Taylor and Francis , 2022 , Article)

The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing ...

Do preexisting antibodies against seasonal coronaviruses have a protective role against SARS-CoV-2 infections and impact on COVID-19 severity?

Gheyath K., Nasrallah ( Elsevier , 2022 , Other)

Because of the emergence of coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), many questions remain unresolved regarding the abundance of cross-reactivity ...

Performance evaluation of novel fluorescent-based lateral flow immunoassay (LFIA) for rapid detection and quantification of total anti-SARS-CoV-2 S-RBD binding antibodies in infected individuals

Shurrab, Farah M; Younes, Nadin; Al-Sadeq, Duaa W; Liu, Na; Qotba, Hamda; ... more authors ... less authors ( Elsevier , 2022 , Article)

The vast majority of the commercially available LFIA is used to detect SARS-CoV-2 antibodies qualitatively. Recently, a novel fluorescence-based LIFA test was developed for quantitative measurement of the total binding ...

Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees

Younes, Nadin; Al-Sadeq, Duaa W.; Shurrab, Farah M.; Zedan, Hadeel T.; Abou-Saleh, Haissam; ... more authors ... less authors ( MDPI , 2022 , Article)

Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). ...