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Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study

Naja, Khaled; Anwardeen, Najeha; Malki, Ahmed M.; Elrayess, Mohamed A. ( Frontiers Media SA , 2024 , Article)

Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ...

Comparing the metabolic signatures of obesity defined by waist circumference, waist-hip ratio, or BMI

Al Hariri, Moustafa; Al-Sulaiti, Haya; Anwardeen, Najeha; Naja, Khaled; Elrayess, Mohamed A. ( John Wiley and Sons Inc , 2024 , Article)

Objective: Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist-hip ...

Metabolomics Profiling of Stages of Coronary Artery Disease Progression

Anlar, Gulsen G.; Anwardeen, Najeha; Al Ashmar, Sarah; Pedersen, Shona; Elrayess, Mohamed A.; ... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)

Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are ...

Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals.

Anwardeen, Najeha; Naja, Khaled; Elrayess, Mohamed A ( Lippincott, Williams & Wilkins , 2024 , Article)

Oxidative stress plays a pivotal role in the development of metabolic syndrome, including heart failure and insulin resistance. The N-terminal fragment of brain natriuretic peptide (NT-proBNP) has been associated with ...