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Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
(
Frontiers Media
, 2022 , Article)
Background: Breast cancer (BC) is the second most common cancer overall. In women, BC is the most prevalent cancer and the leading cause of cancer-related mortality. Triple-negative BC (TNBC) is the most aggressive BC, ...
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
(
IMR Press
, 2022 , Article Review)
Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the ...
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
(
Elsevier
, 2021 , Article)
Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ...
Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime.
(
Frontiers Media
, 2021 , Article)
Exercise training is one of the few therapeutic interventions that improves health span by delaying the onset of age-related diseases and preventing early death. The length of telomeres, the 5'-TTAGGG -3' tandem repeats ...
Editorial: Understanding Molecular Mechanisms in Diabetic Cardiomyopathy (DCM)
(
Frontiers Media S.A.
, 2022 , Article)
Cardiovascular disease is the leading cause of death worldwide, and diabetes, the most common metabolic syndrome, causes a 2–5 times higher risk for heart disease (1). Specifically, cardiovascular complications in people ...
Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer cells
(
Frontiers Media
, 2024 , Article)
Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search ...
Infection with Helicobacter pylori may predispose to atherosclerosis: role of inflammation and thickening of intima-media of carotid arteries
(
Frontiers Media
, 2023 , Article Review)
Atherosclerosis is a major instigator of cardiovascular disease (CVD) and a main cause of global morbidity and mortality. The high prevalence of CVD calls for urgent attention to possible preventive measures in order to ...
Ziziphus nummularia crude and fractionated extracts attenuate the malignant phenotype of human triple-negative breast cancer cells
(
Symposium Cracoviense
, 2024 , Conference)
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has limited therapeutic options. Effects of Ziziphus nummularia against TNBC have not been investigated yet. An ethanolic extract of ...
Impact of Physical Exercise on Gut Microbiome, Inflammation, and the Pathobiology of Metabolic Disorders.
(
The Society for Biomedical
, 2019 , Article Review)
The gastrointestinal tract (GIT) harbors a complex and diverse microbial composition that outnumbers our own body cells and their gene contents. These microbes play a significant role in host metabolism and energy homeostasis. ...
Profiling the Oral Microbiome and Plasma Biochemistry of Obese Hyperglycemic Subjects in Qatar
(
MDPI
, 2019 , Article)
The present study is designed to compare demographic characteristics, plasma biochemistry, and the oral microbiome in obese (N = 37) and lean control (N = 36) subjects enrolled at Qatar Biobank, Qatar. Plasma hormones, ...