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Long-term COVID-19 booster effectiveness by infection history and clinical vulnerability and immune imprinting: a retrospective population-based cohort study

Hiam, Chemaitelly; Ayoub, Houssein H; Tang, Patrick; Coyle, Peter; Yassine, Hadi M; ... more authors ... less authors ( Elsevier , 2023 , Article)

BackgroundLong-term effectiveness of COVID-19 mRNA boosters in populations with different previous infection histories and clinical vulnerability profiles is inadequately understood. We aimed to investigate the effectiveness ...

Protection against Reinfection with the Omicron BA.2.75 Subvariant

Chemaitelly, Hiam; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al-Khatib, Hebah A.; ... more authors ... less authors ( Massachusetts Medical Society , 2023 , Other)

The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) ...

Duration of immune protection of SARS-CoV-2 natural infection against reinfection.

Chemaitelly, Hiam; Nagelkerke, Nico; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; ... more authors ... less authors ( Oxford University Press , 2022 , Article)

The future of the SARS-CoV-2 pandemic hinges on virus evolution and duration of immune protection of natural infection against reinfection. We investigated duration of protection afforded by natural infection, the effect ...

Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections

Qassim, Suelen H.; Hasan, Mohammad R.; Tang, Patrick; Chemaitelly, Hiam; Ayoub, Houssein H.; ... more authors ... less authors ( Frontiers Media , 2022 , Article)

In 2021, Qatar experienced considerable incidence of SARS-CoV-2 infection that was dominated sequentially by the Alpha, Beta, and Delta variants. Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy ...

Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants.

Altarawneh, Heba N; Chemaitelly, Hiam; Ayoub, Houssein H; Hasan, Mohammad R; Coyle, Peter; ... more authors ... less authors ( Massachusetts Medical Society , 2022 , Article)

The BA.4 and BA.5 subvariants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant have shown the capacity of escaping from neutralizing antibodies.1 These subvariants had an ...

Protection from previous natural infection compared with mRNA vaccination against SARS-CoV-2 infection and severe COVID-19 in Qatar: a retrospective cohort study

Hiam, Chemaitelly; Ayoub, Houssein H; AlMukdad, Sawsan; Coyle, Peter; Tang, Patrick; ... more authors ... less authors ( Elsevier , 2022 , Article)

BackgroundUnderstanding protection conferred by natural SARS-CoV-2 infection versus COVID-19 vaccination is important for informing vaccine mandate decisions. We compared protection conferred by natural infection versus ...

Estimating protection afforded by prior infection in preventing reinfection: Applying the test-negative study design.

Ayoub, Houssein H; Tomy, Milan; Chemaitelly, Hiam; Altarawneh, Heba N; Coyle, Peter; ... more authors ... less authors ( Oxford University Press , 2023 , Article)

The COVID-19 pandemic has highlighted the need to use infection testing databases to rapidly estimate effectiveness of prior infection in preventing reinfection ($P{E}_S$) by novel SARS-CoV-2 variants. Mathematical modeling ...

A review of rapid food safety testing: using lateral flow assay platform to detect foodborne pathogens

Younes, Nadin; Yassine, Hadi M.; Kourentzi, Katerina; Tang, Patrick; Litvinov, Dmitri; ... more authors ... less authors ( Taylor and Francis Group , 2023 , Article Review)

The detrimental impact of foodborne pathogens on human health makes food safety a major concern at all levels of production. Conventional methods to detect foodborne pathogens, such as live culture, high-performance liquid ...

Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta SARS-CoV-2 infections: an observational study

Heba N., Altarawneh; Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Hasan, Mohammad R.; ... more authors ... less authors ( Elsevier , 2023 , Article)

BackgroundProtection against SARS-CoV-2 symptomatic infection and severe COVID-19 of previous infection, mRNA two-dose vaccination, mRNA three-dose vaccination, and hybrid immunity of previous infection and vaccination ...

History of primary-series and booster vaccination and protection against Omicron reinfection

Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Coyle, Peter V.; Yassine, Hadi M.; ... more authors ... less authors ( American Association for the Advancement of Science , 2023 , Article)

Laboratory evidence suggests a possibility of immune imprinting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the differences in the incidence of SARS-CoV-2 reinfection in a ...