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AuthorShaikh, Zara
AuthorAshiq, Uzma
AuthorJamal, Rifat Ara
AuthorGul, Sana
AuthorMahroof-Tahir, Mohammad
AuthorSultan, Sadaf
AuthorSalar, Uzma
AuthorKhan, Khalid Mohammed
Available date2023-07-31T12:01:14Z
Publication Date2023-01-01
Publication NameBulletin of the Chemical Society of Ethiopia
Identifierhttp://dx.doi.org/10.4314/bcse.v37i2.6
CitationShaikh, Z., Ashiq, U., Jamal, R. A., Gul, S., Mahroof-Tahir, M., Sultan, S., ... & Khan, K. M. (2023). Synthesis, characterization, lipoxygenase, and tyrosinase inhibitory activities of non-cytotoxic titanium (III) and (IV) hydrazide complexes. Bulletin of the Chemical Society of Ethiopia, 37(2), 315-333.‏
ISSN10113924
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149020136&origin=inward
URIhttp://hdl.handle.net/10576/46444
AbstractTi(III) and (IV) hydrazide complexes were synthesized, characterized, and screened for their tyrosinase and lipoxygenase inhibitory and cytotoxic activities. The geometry of Ti(III) hydrazide complexes is tentatively assigned as octahedral. Magnetic moments were found around 1.7 B.M. and electronic spectral transition in the range of 495-518 nm. Evaluation of Ti(IV) and Ti(III) hydrazide complexes for tyrosinase and lipoxygenase inhibitory activities revealed varying inhibition potential. Hydrazide ligands were inactive against tyrosinase, while significant activity was observed against lipoxygenase (LOX). Good to moderate inhibition activity was observed by Ti(IV) and Ti(III) hydrazide complexes against both enzymes. At the same time, promising results were obtained for Ti(IV) hydrazide complexes against tyrosinase enzymes suggesting their broad application as tyrosinase inhibitors. Complex 4d possess negative inhibition, thus behaving as a tyrosinase activator. The docking results showed a good correlation between complex experimental activities and binding energies. Cytotoxic investigation revealed the non-toxicity of complexes against normal cells.
SponsorZ. Shaikh is thankful to the Higher Education Commission for Indigenous Scholarship No. 213-65456-2PS2-101 under Ph.D. Fellowships for 5000 scholars, HEC (Phase-II). Furthermore, the authors thank the Higher Education Commission of Pakistan for financial support (‘The National Research Grants Program for Universities’, Grant No. 1862/R&D/10).
Languageen
PublisherChemical Society of Ethiopia
SubjectCytotoxicity
Inhibition
Lipoxygenase
Molecular docking
Titanium(III) and titanium(IV) hydrazide complex
Tyrosinase
TitleSynthesis, characterization, lipoxygenase, and tyrosinase inhibitory activities of non- cytotoxic titanium(III) and (IV) hydrazide complexes
TypeArticle
Pagination315-333
Issue Number2
Volume Number37
dc.accessType Open Access


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