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المؤلفBadar, Rooma
المؤلفAshiq, Uzma
المؤلفJamal, Rifat Ara
المؤلفAkhter, Parveen
المؤلفMahroof-Tahir, Mohammad
المؤلفGul, Sana
المؤلفAli, Syed Tahir
تاريخ الإتاحة2023-07-31T12:16:41Z
تاريخ النشر2022-01-01
اسم المنشورMedicinal Chemistry
المعرّفhttp://dx.doi.org/10.2174/1573406417666210216160941
الاقتباسBadar, R., Ashiq, U., Jamal, R. A., Akhter, P., Mahroof-Tahir, M., Gul, S., & Ali, S. T. (2022). In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum (IV)-hydrazide Complexes: Molecular Modeling of Free-Hydrazides Suggested as Potent Lipoxygenase Inhibitor. Medicinal Chemistry, 18(1), 97-114.‏
الرقم المعياري الدولي للكتاب15734064
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123645562&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46446
الملخصBackground: A combination of biologically active ligand and metal in one molecule may increase the activity and reduce the toxicity. Objectives: In this study, the synthesis and characterization of platinum(IV) complexes with bioac-tive hydrazide ligands are discussed. Method: Elemental analysis, conductivity measurements, and spectroscopic studies were used to elucidate the structure of complexes. Results: Our study suggests that hydrazide ligands coordinate with Pt(IV) in a bidentate fashion. The platinum(IV) complexes have octahedral geometry with a metal to ligand ratio of 1:2. Hydrazide ligands were coordinated with central metal platinum(IV) by oxygen of carbonyl group and nitrogen of primary amine. Synthesized complexes exhibited variable DPPH radical scavenging and lipoxy-genase inhibition activity. Furthermore, it is also found that Pt(IV)-hydrazide complexes are more potent superoxide and nitric oxide radical scavengers than their uncoordinated hydrazide ligands, while in the case of lipoxygenase enzyme inhibition, some of the free hydrazide ligands are more active than their respective Pt(IV) complexes. In silico docking technique explores molecular interactions of synthesized ligands in the active site of the lipoxygenase enzyme. Predicted docking energies are in good agreement with experimental data suggesting that in silico studies might be useful for the discovery of therapeutic candidates. Conclusion: Structure-function relationship demonstrates that the radical scavenging and enzyme inhibition activities of the Pt(IV) compounds are affected by the nature of the ligand, position of substituent, electronic and steric effects. However, electronic factors seem to play a more important role than other factors.
اللغةen
الناشرBentham Science Publishers
الموضوعDPPH radical
Hydrazide
In silico docking
Lipoxygenase
Nitric oxide
Platinum(IV)
Superoxide
العنوانIn vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free-Hydrazides Suggested as Potent Lipoxygenase Inhibitor
النوعArticle
الصفحات97-114
رقم العدد1
رقم المجلد18
dc.accessType Abstract Only


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