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المؤلفSharif, Elham
المؤلفRizk, Nasser M.
تاريخ الإتاحة2016-10-02T10:47:54Z
تاريخ النشر2015-05-07
اسم المنشورInternational Journal of Endocrinology
المعرّفhttp://dx.doi.org/10.1155/2015/927805
الاقتباسN. M. Rizk and E. Sharif, “Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women,” International Journal of Endocrinology, vol. 2015, Article ID 927805, 10 pages, 2015.
الرقم المعياري الدولي للكتاب1687-8337
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4805
الملخصLeptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R with 𝑝 values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin
راعي المشروعQatar University Student Fund no. QUST-CAS-SPR-12/13-1.
اللغةen
الناشرHindawi Publishing Corporation
الموضوعLEPTIN
PCOS
العنوانLeptin And Free Leptin Receptor Is Associated With Polycystic Ovary Syndrome In Young Women
النوعArticle
الصفحات10
رقم المجلد2015
ESSN1687-8345
dc.accessType Open Access


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